The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
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Summary
The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target to restore homeostatic microglia.
- Type
- article
- Published
- 2017-09-19
- Cited by
- 2,513
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2754890392
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205427366
Keywords
TREM2, Microglia, Neurodegeneration, Apolipoprotein E, Biology
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Cited by
- TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
- Microglia-Mediated Synapse Loss in Alzheimer's Disease
- Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
- New concepts in macrophage ontogeny in the adult neural retina.
- Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction
- Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1β pathway activation
- Glial Cells as Key Regulators in Neuroinflammatory Mechanisms Associated with Multiple Sclerosis
- Dietary interventions in mitigating the impact of environmental pollutants on Alzheimer's disease - A review.
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- Differential contribution of microglia and monocytes in neurodegenerative diseases
- Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
- Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis
- Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease.
- Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View.
- Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
- Microglia in Alzheimer’s disease
- Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype
- The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer
- Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
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