Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice
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Summary
To investigate miR‐155 in the SOD1 mouse model and human sporadic and familial amyotrophic lateral sclerosis, the objective is to establish an experimental procedure and establish a EMT‐naïve mice model for the disease.
- Type
- article
- Published
- 2014-11-27
- Cited by
- 336
- References
- 63
- OpenAlex
- https://openalex.org/W1545421865
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205345528
Keywords
Microglia, Medicine, Chemistry, Pharmacology, Immunology
References
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- Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling.
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- Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS.
- Targeting of SMAD5 links microRNA-155 to the TGF-β pathway and lymphomagenesis
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- Immunoregulation through extracellular nucleotides.
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- Minocycline selectively inhibits M1 polarization of microglia
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- The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
- Inflammatory processes in amyotrophic lateral sclerosis
- MicroRNA-155 Targets SMAD2 and Modulates the Response of Macrophages to Transforming Growth Factor-β*
- Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease*
- Wild type microglia arrest pathology in a mouse model of Rett syndrome
- MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
- Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
Cited by
- RNA metabolism in neurodegenerative disease
- TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
- Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS
- MicroRNAs mediating CNS inflammation: Small regulators with powerful potential
- Aberrant microRNA expression in spinal muscular atrophy motor neurons
- A Comprehensive Profile of ChIP-Seq-Based Olig2 Target Genes in Motor Neuron Progenitor Cells Suggests the Possible Involvement of Olig2 in the Pathogenesis of Amyotrophic Lateral Sclerosis
- Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
- Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation
- Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions.
- miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction
- RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
- Purinergic contribution to amyotrophic lateral sclerosis.
- A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies
- From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia
- RNA-targeted Therapeutics for ALS
- Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage
- MicroRNA-155 Deletion Reduces Anxiety- and Depressive-Like Behaviors in Mice
- Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis
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