ISGylation – a key to lock the cell gates for preventing the spread of threats
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Summary
Results showing that conjugation of the ubiquitin-like protein ISG15 (ISGylation) tags newly synthesized proteins as suspicious and inhibits exosome secretion to prevent the spreading of pathogens and protein aggregates are reviewed.
- Type
- review
- Published
- 2017-09-15
- Cited by
- 158
- References
- 132
- Access
- Open access
- OpenAlex
- https://openalex.org/W2745948512
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39205729
Keywords
ISG15, Biology, Cell biology, Autophagy, Exosome
References
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- ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells
- Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons
- The role of extracellular vesicles in neurodegenerative diseases.
- Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.
- The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins.
- Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.
- Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective
- Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
- Transcriptome Sequencing to Identify Transcription Factor Regulatory Network and Alternative Splicing in Endothelial Cells Under VEGF Stimulation
- Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
- Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation
- End‐binding protein 1 controls signal propagation from the T cell receptor
- Stabilization and functional modulation of microtubules by microtubule-associated protein 4.
- The Polarity Protein Par1b/EMK/MARK2 Regulates T Cell Receptor-Induced MTOC Polarization
- ISGylation governs the oncogenic function of Ki-Ras in breast cancer
- Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition.
- ISG15 Modulates Development of the Erythroid Lineage
- Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
- The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the anti-viral function of ISG15
Cited by
- ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
- Post-translational add-ons mark the path in exosomal protein sorting
- Antipurinergic therapy for autism-An in-depth review.
- Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
- Inhibiting the Ins and Outs of HIV Replication: Cell-Intrinsic Antiretroviral Restrictions at the Plasma Membrane
- How Does Vaccinia Virus Interfere With Interferon?
- Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation
- Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L
- DiSUMO-LIKE Interacts with RNA-Binding Proteins and Affects Cell-Cycle Progression during Maize Embryogenesis.
- Full-length and defective enterovirus G genomes with distinct torovirus protease insertions are highly prevalent on a Chinese pig farm
- Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens
- Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans
- Host Restriction Factors and Human Immunodeficiency Virus (HIV-1): A Dynamic Interplay Involving All Phases of the Viral Life Cycle.
- Differential antiviral activity of European sea bass interferon‐stimulated 15 protein (ISG15) against RGNNV and SJNNV betanodaviruses
- The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation
- Transcriptomics Reveal Antiviral Gene Induction in the Egyptian Rousette Bat Is Antagonized In Vitro by Marburg Virus Infection
- ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial Homeostasis
- Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins
- Molecular characterization and expression analyses of two homologues of interferon‐stimulated gene ISG15 in Larimichthys crocea (Family: Sciaenidae)
- BAG3 deletion suppresses stem cell-like features of pancreatic ductal adenocarcinoma via translational suppression of ISG15.
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