Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile and Transcriptional Landscape
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Summary
Sarcomatoid renal cell carcinoma (SRCC) segregates by parent subtype, and SccRCC has a fundamentally different early molecular pathogenesis, usually lacking the classic 3p21-25 deletion and showing distinctive mutational and transcriptional profiles.
- Type
- article
- Published
- 2017-07-14
- Cited by
- 95
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W2735736083
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34884210
Keywords
PTEN, Chromophobe cell, Renal cell carcinoma, Biology, Clear cell
References
- BAP1 loss defines a new class of renal cell carcinoma
- Intratumoral Morphologic and Molecular Heterogeneity of Rhabdoid Renal Cell Carcinoma: Challenges for Personalized Therapy
- Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma
- Wild-type VHL Clear Cell Renal Cell Carcinomas Are a Distinct Clinical and Histologic Entity: A 10-Year Follow-up.
- Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma
- Biphasic components of sarcomatoid clear cell renal cell carcinomas are molecularly similar to each other, but distinct from, non‐sarcomatoid renal carcinomas
- Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma
- Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma
- Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
- Therapeutic targeting of cancers with loss of PTEN function
- Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma
- The somatic genomic landscape of chromophobe renal cell carcinoma
- PERCUTANEOUS BIOPSY OF PRIMARY TUMOR IN METASTATIC RENAL CELL CARCINOMA TO PREDICT HIGH RISK PATHOLOGIC FEATURES: COMPARISON WITH NEPHRECTOMY ASSESSMENT
- Mutational landscape and significance across 12 major cancer types
- Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma.
- The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling
- Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
- Effect of p53 Status on Tumor Response to Antiangiogenic Therapy
- Cytoreductive Nephrectomy for Kidney Cancer With Sarcomatoid Histology—Is Up-Front Resection Indicated and, if Not, is it Avoidable?
- Integrated molecular analysis of clear-cell renal cell carcinoma
Cited by
- Kidney cancer: Deciphering sarcomatoid RCC
- Sarcomatoid Renal Cell Carcinoma: The Apple Doesn't Fall Far from the Tree
- Carcinosarcomas and Related Cancers: Tumors Caught in the Act of Epithelial-Mesenchymal Transition.
- Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
- Epidemiology, biology and treatment of sarcomatoid RCC: current state of the art
- Chromophobe renal cell carcinoma with sarcomatoid differentiation containing various heterologous components
- Epigenetic modifiers: activities in renal cell carcinoma
- Discovering novel valid biomarkers and drugs in patient-centric genomic trials: the new epoch of precision surgical oncology.
- Regulation of PTEN expression by noncoding RNAs
- Ki-67 index and percentage of sarcomatoid differentiation were two independent prognostic predictors in sarcomatoid renal cell carcinoma
- Identification of alterations in the nucleotide sequence of the chromatin remodeling gene PBRM1 in clear cell renal cell carcinoma patients
- Mutations in renal cell carcinoma.
- Immune Checkpoint Blockade Is Associated With Durable Responses in Pulmonary Sarcomatoid Carcinoma.
- Patterns of Presentation and Treatment Outcomes of Non-clear-cell Renal Cell Carcinoma and Sarcomatoid Renal Cell Carcinoma Patients in 2 Tertiary Referral Centers in Sydney, Australia.
- MDM2 amplification and immunohistochemical expression in sarcomatoid renal cell carcinoma.
- Renal Cell Carcinoma with Sarcomatoid Features: Finally New Therapeutic Hope?
- JAK2/PD-L1/PD-L2 (9p24.1) Amplifications in Renal Cell Carcinomas with Sarcomatoid Transformation: Implications for Clinical Management
- Precision oncology in patients with nonmetastatic disease: emerging reality or illusion.
- A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component
- Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma
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