Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma
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Summary
Exome sequencing provides evidence that sarcomatoid elements arise from dedifferentiation of carcinomatous ccRCCs and implicate specific genes in this process, which has implications for the treatment of patients with these poor-prognosis cancers.
- Type
- article
- Published
- 2016-01-10
- Cited by
- 127
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W26864202
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28035839
Keywords
Humanities, Political science, Philosophy
References
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- Clinically Non-Metastatic Renal Cell Carcinoma With Sarcomatoid Dedifferentiation: Natural History and Outcomes after Surgical Resection with Curative Intent
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- Precision medicine from the renal cancer genome
- Molecular profiling of renal cell carcinoma: building a bridge towards clinical impact
- Dual Chromatin and Cytoskeletal Remodeling by SETD2
- Integration of Recurrent Somatic Mutations with Clinical Outcomes: A Pooled Analysis of 1049 Patients with Clear Cell Renal Cell Carcinoma
- Mesothelioma families without inheritance of a BAP1 predisposing mutation.
- High fidelity of driver chromosomal alterations among primary and metastatic renal cell carcinomas: implications for tumor clonal evolution and treatment
- Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
- Gene of the month: BAP1
- Presence of sarcomatoid differentiation as a prognostic indicator for survival in surgically treated metastatic renal cell carcinoma
- A randomized phase 2 study of MK-2206 versus everolimus in refractory renal cell carcinoma
- Rhabdoid and Undifferentiated Phenotype in Renal Cell Carcinoma: Analysis of 32 Cases Indicating a Distinctive Common Pathway of Dedifferentiation Frequently Associated With SWI/SNF Complex Deficiency
- Comprehensive genomic profiling of salivary mucoepidermoid carcinomas reveals frequent BAP1, PIK3CA, and other actionable genomic alterations
- Pulmonary Sarcomatoid Carcinomas Commonly Harbor Either Potentially Targetable Genomic Alterations or High Tumor Mutational Burden as Observed by Comprehensive Genomic Profiling
- Comprehensive Analysis of Survival Outcomes in Non–Clear Cell Renal Cell Carcinoma Patients Treated in Clinical Trials
- Outcomes of Patients with Renal Cell Carcinoma and Sarcomatoid Dedifferentiation Treated with Nephrectomy and Systemic Therapies Over Three Decades: Comparison Between the Cytokine (1987–2005) and the Targeted Therapy (2006–2015) Eras
- Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm
- A comprehensive genomic pan-cancer classification using The Cancer Genome Atlas gene expression data
- Renal cell carcinoma
- Preservation of truncal genomic alterations in clear cell and papillary renal cell carcinomas with sarcomatoid features: An intra‐ and intertumoral, multifocal fluorescence in situ hybridization analysis reveals limited genetic heterogeneity
- Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile and Transcriptional Landscape
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