Clonal hematopoiesis and risk for atherosclerotic cardiovascular disease
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Summary
The presence of CHIP in peripheral‐blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans and with accelerated atherosclerosis in mice.
- Type
- article
- Published
- 2017-06-21
- Cited by
- 2,222
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2628145035
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205101862
Keywords
Medicine, Myocardial infarction, Internal medicine, Coronary artery disease, Bone marrow
References
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- Lifetime Risk and Years Lived Free of Total Cardiovascular Disease
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- The Framingham Offspring Study. Design and preliminary data.
- Transport, interactions and retention of plasma proteins in the intima: the barrier function of the internal elastic lamina.
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- Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice
- Dnmt3a is essential for hematopoietic stem cell differentiation
- The BioImage Study: novel approaches to risk assessment in the primary prevention of atherosclerotic cardiovascular disease--study design and objectives.
- Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.
- Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
Cited by
- Clonal hematopoiesis of indeterminate potential associated mutations and risk of comorbidities in patients with myelodysplastic syndrome
- DNA hydroxymethylation combined with carotid plaques as a novel biomarker for coronary atherosclerosis
- Clonal hematopoiesis confers an increased mortality risk in orthotopic heart transplant recipients
- CHIP-ping Away at Atherosclerosis.
- Atherosclerosis: Somatic mutations in haematopoietic cells contribute to atherosclerosis
- Clonal chromosomal abnormalities appearing in Philadelphia chromosome-negative metaphases during CML treatment.
- Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Tet2 restrains inflammatory gene expression in macrophages.
- MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice
- Distinguishing CHIP from Myeloid Neoplasia
- Leukaemia: Vitamin C regulates stem cells and cancer
- Genetic Risk Stratification and Prevention of CAD: An Idea Whose Time Is Now.
- The maturation of a ‘neural–hematopoietic’ inflammatory axis in cardiovascular disease
- Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis.
- Risk Factors for and Management of MPN-Associated Bleeding and Thrombosis
- Prognostication and Initiation of Therapy in Polycythemia Vera: Do We Have it Right?
- Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications
- Stem cells and heart disease - Brake or accelerator?
- Clonality in context: hematopoietic clones in their marrow environment.
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