Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.
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Summary
Assessment of the osteocyte-specific RankL/OPG ratio showed that the steroid-induced osteoporosis in its late progressive phase stimulates RANKL expression in osteocytes, which can contribute to further explain the success of sclerostin antibodies in treating osteopootic patients despite increased osteocytes-expressed RANKG.
- Type
- article
- Published
- 2017-08-01
- Cited by
- 20
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2625382104
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24320354
Keywords
RANKL, Osteoprotegerin, Sclerostin, Osteocyte, Endocrinology
References
- RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.
- Large animal model for osteoporosis in humans: the ewe.
- Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats
- Dynamics of the Transition from Osteoblast to Osteocyte
- Osteoporosis-An Epidemiological Perspective: A Review
- Glucocorticoid-treated sheep as a model for osteopenic trabecular bone in biomaterials research.
- Changes in osteocyte density correspond with changes in osteoblast and osteoclast activity in an osteoporotic sheep model
- Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1.
- Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis.
- Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model.
- Animal models for fracture treatment in osteoporosis
- Structure, expression, and regulation of the major noncollagenous matrix proteins of bone.
- Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?
- Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis
- MEPE’s Diverse Effects on Mineralization
- Effects of Multi-Deficiencies-Diet on Bone Parameters of Peripheral Bone in Ovariectomized Mature Rat
- Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
- RANKL/OPG; Critical role in bone physiology
- The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China
- Mechanosensation and transduction in osteocytes.
Cited by
- Preclinical and Translational Studies in Small Ruminants (Sheep and Goat) as Models for Osteoporosis Research
- An Optimized Approach to Perform Bone Histomorphometry
- Analysis of microscopic bone properties in an osteoporotic sheep model: a combined biomechanics, FE and ToF-SIMS study
- The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis
- Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model
- Rosamultin Attenuates Acute Hypobaric Hypoxia-Induced Bone Injuries by Regulation of Sclerostin and Its Downstream Signals
- Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research.
- Novel in vitro microfluidic platform for osteocyte mechanotransduction studies.
- Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model
- Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae
- Osteoporosis Preclinical Research: A Systematic Review on Comparative Studies Using Ovariectomized Sheep
- Landscape of Well-Coordinated Fracture Healing in a Mouse Model Using Molecular and Cellular Analysis
- The Potential of Chickpea (Cicer arietinum L.) for Anti-Osteoporotic Agent in Post-Menopausal Women: A Systematic Review of In Vivo Study
- High molecular weight hyaluronic acid alleviates ovariectomy-induced bone loss in mice
- The effect of bone marrow mesenchymal stem cell-derived extracellular vesicles on bone mineral density and microstructure in osteoporosis: A systematic review and meta-analysis of preclinical studies
- Assessment of Lumbar Vertebrae L1–L7 and Proximal Femur Microstructure in Sheep as a Large Animal Model for Osteoporosis Research
- Clinical Performance of Ultra-Porous TiO2 Scaffold as Bone Graft Substitute in Human Alveolar Ridge Preservation-A Feasibility Study.
- Osteoporose und Inflammation
- Running title: EVALUATION OF SHEEP FOR OSTEOPOROSIS RESEARCH Academy Section: BIOMEDICAL SCIENCES
- Title: The Heparan Sulfate Proteoglycan Syndecan-1 Influences Local Bone Cell Communication via the RANKL/OPG Axis Short title: Syndecan-1 in local bone cell communication
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