MEPE’s Diverse Effects on Mineralization
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Summary
The importance of posttranslational modification for the site-specific activity of MEPE and its ASARM peptide is demonstrated, with the phosphorylated intact protein an effective promoter of mineralization in the gelatin gel diffusion system, while the AS ARM peptide was an effective inhibitor.
- Type
- article
- Published
- 2009-12-09
- Cited by
- 64
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988253880
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12759611
Keywords
Peptide, Chemistry, Biochemistry, Mineralization (soil science), Serine
References
- Importance of Phosphorylation for Osteopontin Regulation of Biomineralization
- The determination of metals in blood serum by atomic absorption spectroscopy—I. Calcium
- Matrix Macromolecules in Hard Tissues Control the Nucleation and Hierarchical Assembly of Hydroxyapatite*
- MEPE has the properties of an osteoblastic phosphatonin and minhibin.
- MEPE‐ASARM Peptides Control Extracellular Matrix Mineralization by Binding to Hydroxyapatite: An Inhibition Regulated by PHEX Cleavage of ASARM
- Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator.
- MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia.
- Concentration-dependent effects of dentin phosphophoryn in the regulation of in vitro hydroxyapatite formation and growth.
- Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone
- Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel.
- Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP).
- Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation.
- Phosphorylation of Phosphophoryn Is Crucial for Its Function as a Mediator of Biomineralization*
- ASARM‐truncated MEPE and AC‐100 enhance osteogenesis by promoting osteoprogenitor adhesion
- Nucleation of hydroxyapatite by bone sialoprotein.
- Evidence of downregulation of matrix extracellular phosphoglycoprotein during terminal differentiation in human osteoblasts.
- Dentin Sialoprotein (DSP) Has Limited Effects on In Vitro Apatite Formation and Growth
- Diffusion Systems for Evaluation of Biomineralization
- A Synthetic Peptide Fragment of Human MEPE Stimulates New Bone Formation In Vitro and In Vivo
- A review of protein structure and gene organisation for proteins associated with mineralised tissue and calcium phosphate stabilisation encoded on human chromosome 4.
Cited by
- Role of MEPE in chondrocyte matrix mineralisation
- Impact de l'extinction génique de la sialoprotéine osseuse (BSP) sur la différenciation des ostéoblastes et l'ostéogenèse in vitro : développement et validation d'un bioréacteur pour la culture ostéoblastique en trois dimensions
- Phosphatonins: physiological role and pathological changes.
- Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif
- POST-TRANSLATIONAL MODIFICATION OF OSTEOPONTIN: EFFECTS on in vitro HYDROXYAPATITE FORMATION and GROWTH
- Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone.
- PHEX Mimetic (SPR4-Peptide) Corrects and Improves HYP and Wild Type Mice Energy-Metabolism
- SPR4-peptide Alters Bone Metabolism of Normal and HYP Mice
- Effects of lactic acid and glycolic acid on human osteoblasts: A way to understand PLGA involvement in PLGA/calcium phosphate composite failure
- Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in‐situ synchrotron X‐ray scattering and backscattered electron imaging
- Dentin: Structure, Composition and Mineralization
- ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate.
- The rachitic tooth.
- MEPE-Derived ASARM Peptide Inhibits Odontogenic Differentiation of Dental Pulp Stem Cells and Impairs Mineralization in Tooth Models of X-Linked Hypophosphatemia
- ASARM Mineralization Hypothesis: A Bridge Too Far?
- The Impairment of Osteogenesis in Bone Sialoprotein (BSP) Knockout Calvaria Cell Cultures Is Cell Density Dependent
- Mineralisation of soft and hard tissues and the stability of biofluids.
- SEPARATION OF NEWLY FORMED BONE FROM OLDER COMPACT BONE REVEALS CLEAR COMPOSITIONAL DIFFERENCES IN BONE MATRIX
- Is interaction between age-dependent decline in mechanical stimulation and osteocyte–estrogen receptor levels the culprit for postmenopausal-impaired bone formation?
- The effect of matrix extracellular phosphoglycoprotein and its downstream osteogenesis-related gene expression on the proliferation and differentiation of human dental pulp cells.
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