Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
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Summary
It is shown that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose and can potentially be extended to other pathogens and tissue systems.
- Type
- article
- Published
- 2017-04-25
- Cited by
- 62
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2610140032
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28976023
Keywords
Biology, Chlamydia trachomatis, Induced pluripotent stem cell, Transcriptome, Pathogen
References
- Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors
- Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter's syndrome are viable but show aberrant gene expression.
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- Pathway-GPS and SIGORA: identifying relevant pathways based on the over-representation of their gene-pair signatures
- Apoptosis resistance in Chlamydia-infected cells: a fate worse than death?
- Significant Roles Played by IL-10 in Chlamydia Infections
- Bi-allelic gene targeting in mouse embryonic stem cells
- Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP‐1 with an MLL‐AF9 translocation
- Distinctive Profiles of Infection and Pathology in Hamsters Infected with Clostridium difficile Strains 630 and B1
- Expression of interferon regulatory factors and indoleamine 2,3-dioxygenase in Chlamydia trachomatis-infected synovial fibroblasts
- Chlamydia trachomatis infection: host immune responses and potential vaccines
- Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism
- Genetic Transformation of a Clinical (Genital Tract), Plasmid-Free Isolate of Chlamydia trachomatis: Engineering the Plasmid as a Cloning Vector
- Intracellular Survival and Persistence of Chlamydia muridarum Is Determined by Macrophage Polarization
- Host Translation at the Nexus of Infection and Immunity
- IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
- Persistent infection of Chlamydia in reactive arthritis
- Case Report: In Situ Hybridization for Detection of Inapparent Infection With Chlamydia trachomatis in Synovial Tissue of a Patient With Reiter's Syndrome
- Alteration of Chlamydia trachomatis biologic behavior in synovial membranes. Suppression of surface antigen production in reactive arthritis and Reiter's syndrome.
Cited by
- Male genital tract immune response against Chlamydia trachomatis infection.
- Human Induced Pluripotent Stem Cell–Derived Macrophages for Unraveling Human Macrophage Biology
- Development of Novel Predictive 2D and 3D in Vitro Models For Anti-Leishmanial Drug Testing
- Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection
- A Simple Multistep Protocol for Differentiating Human Induced Pluripotent Stem Cells into Functional Macrophages.
- Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development.
- Advances and challenges in targeting IRF5, a key regulator of inflammation
- Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells.
- Sustained and regulated gene expression by Tet-inducible "all-in-one" retroviral vectors containing the HNRPA2B1-CBX3 UCOE®.
- Immunobiology of monocytes and macrophages during Chlamydia trachomatis infection.
- Development of innate immune cells from human pluripotent stem cells
- Ocular Chlamydia trachomatis infection: elimination with mass drug administration
- Using a Systems Biology Approach To Study Host-Pathogen Interactions
- Clear Victory for Chlamydia: The Subversion of Host Innate Immunity
- Human‐induced pluripotent stem cell‐derived blood products: state of the art and future directions
- An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation
- A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection
- Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2
- IRF5 Promotes Influenza Virus-Induced Inflammatory Responses in Human Induced Pluripotent Stem Cell-Derived Myeloid Cells and Murine Models
- The role of small non-coding RNA in African swine fever virus infection
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