Induced Pluripotent Stem Cell Derived Macrophages as a Cellular System to Study Salmonella and Other Pathogens
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Summary
It is concluded that iPSDMs can support productive Salmonella infection and propose this as a flexible system to study host/pathogen interactions and can provide a flexible and practical cellular platform for assessing host responses in multiple genetic backgrounds.
- Type
- article
- Published
- 2015-05-06
- Cited by
- 58
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W266652616
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5988868
Keywords
Biology, Salmonella, Pathogen, Induced pluripotent stem cell, Microbiology
References
- Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG.
- Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease
- The Expression of Exogenous Genes in Macrophages: Obstacles and Opportunities
- Gaucher iPSC-derived macrophages produce elevated levels of inflammatory mediators and serve as a new platform for therapeutic development
- Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans
- Construction of broad-host-range plasmid vectors for easy visible selection and analysis of promoters
- Therapy of Peritoneally Disseminated Colon Cancer by TAP-Deficient Embryonic Stem Cell–Derived Macrophages in Allogeneic Recipients
- Differences in the state of differentiation of THP‐1 cells induced by phorbol ester and 1,25‐dihydroxyvitamin D3
- Innate immunity to intracellular pathogens: macrophage receptors and responses to microbial entry
- Immunity to salmonellosis
- Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis
- Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood.
- Application of iPS cell-derived macrophages to cancer therapy
- Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development.
- Construction of broad-host-range vectors for the selection of divergent promoters.
- Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
- Activation of murine macrophages by Neisseria meningitidis and IFN‐γ in vitro: distinct roles of class A scavenger and Toll‐like pattern recognition receptors in selective modulation of surface phenotype
- Depletion of TGF-β from fetal bovine serum
- Generation of microglial cells from mouse embryonic stem cells
- A Salmonella Typhimurium-Typhi Genomic Chimera: A Model to Study Vi Polysaccharide Capsule Function In Vivo
Cited by
- Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.
- Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets
- The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development.
- Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
- Using Raw 264.7 Macrophages Infected with Salmonella enterica Serotype Typhimurium and 4,[5],12:i:- to Study Bacterial Invasion and Effects on Macrophage Survival, Nitric Oxide Response and Proinflammatory Cytokine Secretion
- Human Induced Pluripotent Stem Cell–Derived Macrophages for Unraveling Human Macrophage Biology
- Development of Novel Predictive 2D and 3D in Vitro Models For Anti-Leishmanial Drug Testing
- A Simple Multistep Protocol for Differentiating Human Induced Pluripotent Stem Cells into Functional Macrophages.
- Brown and beige fat: From molecules to physiology and pathophysiology.
- Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
- Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells.
- Differentiation of Human-Induced Pluripotent Stem Cells to Macrophages for Disease Modeling and Functional Genomics
- GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
- Development of innate immune cells from human pluripotent stem cells
- Mycobacterium tuberculosis infection of host cells in space and time
- Using a Systems Biology Approach To Study Host-Pathogen Interactions
- Using genetic and genomic approaches to understand haematopoietic cellular biology and dysregulation in disease
- A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection
- Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2
- New Drugs for an Old Foe: Mycobacterium tuberculosis Meets PSC-Derived Macrophages
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