New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis

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Summary

It is proposed that alcohol-induced decrease in α-MSH levels may trigger a cascade of glial inflammatory pathways that culminate in altered gliotransmission in the ventral tegmental area and nucleus accumbens (NAc), contributing to increase the vulnerability to alcohol dependence and addiction in the adolescence and adulthood.

Type
article
Published
2017-04-05
Cited by
16
References
348
Access
Open access

Keywords

Ventral tegmental area, Nucleus accumbens, Addiction, Melanocortin, Dopaminergic

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