Targeting the molecular chaperone SlyD to inhibit bacterial growth with a small molecule
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Summary
It is found that a Cu2+ complex readily crosses the bacterial cell wall and inhibits SlyD, which is a molecular chaperone, cis/trans peptidyl prolyl isomerise (PPIase) and involved in various other metabolic pathways.
- Type
- article
- Published
- 2017-02-08
- Cited by
- 14
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W2586257300
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19186732
Keywords
Chaperone (clinical), Small molecule, Cell biology, Chemistry, Biology
References
- The twin-arginine translocation system and its capability for protein secretion in biotechnological protein production
- Synthesis, characterization, plasmid cleavage and cytotoxicity of cancer cells by a copper(II) complex of anthracenyl-terpyridine.
- Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface
- Protein NMR Techniques
- Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides
- An Escherichia coli protein consisting of a domain homologous to FK506-binding proteins (FKBP) and a new metal binding motif.
- Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death.
- Antimicrobial resistance: a global multifaceted phenomenon
- Investigation of proteins in living bacteria with in-cell NMR experiments.
- The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex
- Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1
- NMR relaxation unravels interdomain crosstalk of the two domain prolyl isomerase and chaperone SlyD.
- Escherichia coli MazF Leads to the Simultaneous Selective Synthesis of Both “Death Proteins” and “Survival Proteins”
- The new bacterial cell biology: moving parts and subcellular architecture.
- Synthesis and structure of a water-soluble hexanuclear silver(I) nicotinate cluster comprised of a "cyclohexane-chair"-type of framework, showing effective antibacterial and antifungal activities: use of "sparse matrix" techniques for growing crystals of water-soluble inorganic complexes.
- Presenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities
- Synthesis of novel gold(I) complexes derived by AgCl-elimination between [AuCl(PPh3)] and silver(I) heterocyclic carboxylates, and their antimicrobial activities. Molecular structure of [Au(R,S-Hpyrrld)(PPh3)] (H2pyrrld = 2-pyrrolidone-5-carboxylic acid)
- Cellular processing of platinum anticancer drugs
- Advances in copper complexes as anticancer agents.
- Interaction of cisplatin with human superoxide dismutase.
Cited by
- Screening of Neem extracts for microbial anti-chaperone activity by employing in vitro enzyme refolding assay
- A small-molecule acts as a 'roadblock' on DNA, hampering its fundamental processes.
- The identification and characterization of microbial FK506-binding proteins
- Fermentation products in the cystic fibrosis airways induce aggregation and dormancy-associated expression profiles in a CF clinical isolate of Pseudomonas aeruginosa
- A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53
- In-Cell NMR: Analysis of Protein–Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation
- Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections
- Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
- A Novel Small Molecule, LCG-N25, Inhibits Oral Streptococcal Biofilm
- Analysis of temporal gene regulation of Listeria monocytogenes revealed distinct regulatory response modes after exposure to high pressure processing
- Folding and Stability of Ankyrin Repeats Control Biological Protein Function
- The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases
- Proteostasis-targeted antibacterial strategies.
- Small molecule induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53
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