CENP-A associated lncRNAs influence chromosome segregation in human cells
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Summary
High throughput approaches are used to identify and describe lncRNAs associated with the centromere specific histone variant CENP-A that arise from the transcription of specific centromeres at early G1, which it is shown are physically associated with centromres, and which are functionally necessary for accurate chromosome segregation.
- Type
- preprint
- Published
- 2017-01-03
- Cited by
- 5
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2571097028
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90530103
Keywords
Centromere, Biology, Chromosome segregation, Genetics, Transcription (linguistics)
References
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- Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore
- A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
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- The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line
- Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres
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- Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division
- Tiggers and DNA transposon fossils in the human genome.
- An RNA Polymerase III-Dependent Heterochromatin Barrier at Fission Yeast Centromere 1
- Crystal structure of the CENP‐B protein–DNA complex: the DNA‐binding domains of CENP‐B induce kinks in the CENP‐B box DNA
- Facilitation of chromatin dynamics by SARs.
Cited by
- Transcribing Centromeres: Noncoding RNAs and Kinetochore Assembly.
- Point centromere activity requires an optimal level of centromeric noncoding RNA
- Centromeric RNA and its function at and beyond centromeric chromatin.
- Centromeric Transcription: A Conserved Swiss-Army Knife
- Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells
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