Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health.
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Summary
It is proposed that a better understanding of how mutations affect the structure, function, and formation of multiprotein complexes provides novel opportunities for tackling mutations, including the development of small-molecule drugs targeted specifically to mutated PPIs.
- Type
- review
- Published
- 2017-09-01
- Cited by
- 149
- References
- 182
- Access
- Open access
- OpenAlex
- https://openalex.org/W2558879065
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20694349
Keywords
Multiprotein complex, Protein–protein interaction, Phenotype, Biology, Small molecule
References
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Cited by
- mCSM–NA: predicting the effects of mutations on protein–nucleic acids interactions
- Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance
- Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design
- Investigating the Influence of Hotspot Mutations in Protein-Protein Interaction of IDH1 Homodimer Protein: A Computational Approach.
- A photo-cross-linking approach to monitor folding and assembly of newly synthesized proteins in a living cell
- Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection
- Flex ddG: Rosetta Ensemble-Based Estimation of Changes in Protein-Protein Binding Affinity Upon Mutation
- Genetic variants and protein-protein interactions: a multidimensional network-centric view.
- Prediction and Optimization of Pharmacokinetic and Toxicity Properties of the Ligand.
- Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam
- Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy.
- Analysis of single amino acid variations in singlet hot spots of protein‐protein interfaces
- Structural Principles Governing Disease-Causing Germline Mutations.
- CDB-a database for protein heterodimeric complexes.
- Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing
- Progress in biophysics and molecular biology: A brief history of the journal.
- Generating quantitative binding landscapes through fractional binding selections, deep sequencing and data normalization
- dbHDPLS: A database of human disease-related protein-ligand structures
- Finding the ΔΔG spot: Are predictors of binding affinity changes upon mutations in protein–protein interactions ready for it?
- A domain based protein structural modelling platform applied in the analysis of alternative splicing
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