Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study Among Over 51 000 Individuals of European Ancestry
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Summary
The results demonstrate significant and clinically relevant incremental discriminative/predictive capability of 4 multilocus GRSs for incident CHD among subjects of European ancestry.
- Type
- article
- Published
- 2016-10-25
- Cited by
- 71
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2544594608
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22825848
Keywords
Hazard ratio, Medicine, Framingham Risk Score, Confidence interval, Cohort
References
- Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
- Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history
- Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.
- ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study
- Ideal Cardiovascular Health Predicts Lower Risks of Myocardial Infarction, Stroke, and Vascular Death across Whites, Blacks and Hispanics: the Northern Manhattan Study
- A Bias Corrected Net Reclassification Improvement for Clinical Subgroups
- Variants of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of coronary heart disease: A meta-analysis.
- Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: A population-based study in Greece
- Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands.
- Assessment of the value of a genetic risk score in improving the estimation of coronary risk
- Patient compliance based on genetic medicine: a literature review
- A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies
- Economic Evaluation of Cardio inCode®, a Clinical-Genetic Function for Coronary Heart Disease Risk Assessment
- Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population.
- Next generation genome-wide association tool: Design and coverage of a high-throughput European-optimized SNP array
- Large-scale association analysis identifies new risk loci for coronary artery disease
- Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example
- Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
- Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm
- Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.
Cited by
- Predicting Incident Coronary Heart Disease Many Markers at a Time.
- Leveraging information from genetic risk scores of coronary atherosclerosis
- A decade of progress on the genetic basis of coronary artery disease. Practical insights for the internist.
- Genética de la cardiopatía isquémica: del conocimiento actual a las implicaciones clínicas
- Cardiovascular Risk Assessment.
- The Genetics of Ischemic Heart Disease: From Current Knowledge to Clinical Implications.
- A clinical-genetic approach to assessing cardiovascular risk in patients with CKD
- Nutriepigenomics Advances into Personalized Nutrition
- Genetic Risk Stratification and Prevention of CAD: An Idea Whose Time Is Now.
- Genetic Risk Scores in Premature Coronary Artery Disease Still Only One Piece of the Prevention Puzzle
- Valor predictivo de la albúmina plasmática, la vitamina D y las apolipoproteínas A y B como biomarcadores de riesgo coronario en el estudio REGICOR
- Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry
- Hypertension genomics and cardiovascular prevention.
- Personalized Approach to Statin Selection in Primary Prevention: Genetic Risk Scores Vs Imaging Risk Scores
- Analysis of Plasma Albumin, Vitamin D, and Apolipoproteins A and B as Predictive Coronary Risk Biomarkers in the REGICOR Study.
- The Genetic Sphygmomanometer: an argument for routine genome-wide genotyping in the population and a new view on its use to inform clinical practice
- Additional value of a combined genetic risk score to standard cardiovascular stratification
- Electronic health record access by patients as an indicator of information seeking and sharing for cardiovascular health promotion in social networks: Secondary analysis of a randomized clinical trial
- Polygenic risk scores in coronary artery disease.
- Presentations and Posters
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