The Cholesterol-Lowering Effect of Alisol Acetates Based on HMG-CoA Reductase and Its Molecular Mechanism
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Summary
Alisol acetate results suggest that alisol acetates lower the TC level via inhibiting the activity of HMG-CoA reductase by its prototype drug, which may exhibit an inhibition effect via directly and competitively binding to HMG -CoA.
- Type
- article
- Published
- 2016-10-30
- Cited by
- 35
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W2542738055
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5764569
Keywords
HMG-CoA reductase, Mechanism (biology), Chemistry, Reductase, Cholesterol
References
- Lipid-lowering effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, in high-fat diet-induced hyperlipidemic hamsters.
- Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation.
- The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitis.
- Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat
- Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress
- Does estradiol have an impact on the dipeptidyl peptidase IV enzyme activity of the Prevotella intermedia group bacteria?
- Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: a review.
- Impaired Regulation of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Degradation in Lovastatin-resistant Cells*
- Paraoxonase-1 Enzyme Activity Assay for Clinical Samples: Validation and Correlation Studies
- Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis.
- A new triterpenoid from Alisma orientale and their antibacterial effect
- A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats.
- Detection of 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein Cm-HMGR during fruit development in melon (Cucumis melo L.)
- Randomly arrayed G-quadruplexes for label-free and real-time assay of enzyme activity.
- The binding mechanisms of plasma protein to active compounds in Alismaorientale rhizomes (Alismatis Rhizoma).
- Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury
- Characterization and function of the 3-hydroxy-3-methylglutaryl-CoA reductase gene in Alisma orientale (Sam.) Juz. and its relationship with protostane triterpene production.
- Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats
- Effects of Extract from Cole Pollen on Lipid Metabolism in Experimental Hyperlipidemic Rats
- Influence of pH and sequence in peptide aggregation via molecular simulation.
Cited by
- Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology
- An Integrated Lipidomics and Phenotype Study Reveals Protective Effect and Biochemical Mechanism of Traditionally Used Alisma orientale Juzepzuk in Chronic Kidney Disease
- Studies on the lipid-regulating mechanism of alisol-based compounds on lipoprotein lipase.
- Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats
- Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G1 cell cycle arrest and apoptosis: A quantitative proteomic study
- Identification of the lipid-lowering component of triterpenes from Alismatis rhizoma based on the MRM-based characteristic chemical profiles and support vector machine model
- Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway
- Pharmacological Activities of Alisma orientale against Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: Literature Review
- Apple phlorizin reduce plasma cholesterol by down-regulating hepatic HMG-CoA reductase and enhancing the excretion of fecal sterols
- The antitumor molecular mechanism of Alisma orientalis with c-myc DNA: multi-spectroscopic analysis and molecular simulation
- Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes
- Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database
- Molecular insight into the mechanism of lipid regulating effect of Alisma orientalis based on ACAT.
- Triterpenoids From Alisma Species: Phytochemistry, Structure Modification, and Bioactivities
- Activation of estrogen receptor α (ERα) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation.
- Alisma genus: Phytochemical constituents, biosynthesis, and biological activities
- Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes
- Triterpenoids from Alisma orientale and their NF-кB Inhibitory Activity
- Ameliorative Effect of Trigonella Foenum Graecum L. on Lipid Profile, Liver Histology and LDL-Receptor Gene Expression in High Cholesterol-Fed Hamsters.
- Integrating Network Pharmacology and RT-qPCR Analysis to Investigate the Mechanisms Underlying ZeXie Decoction-Mediated Treatment of Non-alcoholic Fatty Liver Disease
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