Impaired Regulation of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Degradation in Lovastatin-resistant Cells*

Keywords

Lovastatin, Reductase, Coenzyme A, Degradation (telecommunications), HMG-CoA reductase

References

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Cited by

• RhoA, B, and C in cancer: Study of statin-induced changes in Rho signaling, and identification of isoform-specific Rho effectorsStephanie Turner — 2009
• Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells.Leen Delang, Els Scheers, Mareike Grabner — 2015
• The Ubiquitin-Proteasome Pathway Mediates the Regulated Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase*Tommer Ravid, Ram Doolman, Rachel Avner — 2000
• Partial silencing of a hydroxy-methylglutaryl-CoA reductase-encoding gene in Trichoderma harzianum CECT 2413 results in a lower level of resistance to lovastatin and lower antifungal activity.Rosa E. Cardoza, María Rosa Hermosa, Juan Antonio Vizcaíno — 2007
• Inositol 1,4,5-Trisphosphate Receptor Ubiquitination Is Mediated by Mammalian Ubc7, a Component of the Endoplasmic Reticulum-associated Degradation Pathway, and Is Inhibited by Chelation of Intracellular Zn2+*Jack M. Webster, Swati Tiwari, Allan M. Weissman — 2003
• Metabolically Regulated Endoplasmic Reticulum-associated Degradation of 3-Hydroxy-3-methylglutaryl-CoA ReductaseGil S. Leichner, Rachel Avner, Dror Harats — 2011
• Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatusSabiha Yasmin, Laura Alcázar‐Fuoli, Mario Gründlinger — 2011
• Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells.Tommer Ravid, Adili Tsaba, Peter Gee — 2003
• Ubiquitin Is Conjugated by Membrane Ubiquitin Ligase to Three Sites, including the N Terminus, in Transmembrane Region of Mammalian 3-Hydroxy-3-methylglutaryl Coenzyme A ReductaseRam Doolman, Gil S. Leichner, Rachel Avner — 2004
• Modificación del comportamiento celular bajo el efecto de estatinas en células de pared arterial (II). Alteraciones estructurales del citoesqueletoAlvarez-Sala Jl, Carlos Recarte García-Andrade, Granada Álvarez Novés — 2012
• Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.A Gamliel, Carmit Teicher, Tobias Hartmann — 2003
• HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosisW. Wei‐Lynn Wong, Jim Dimitroulakos, MD Minden — 2002
• Increased expression of presenilin 2 inhibits protein synthesis.Amir Gamliel, Carmit Teicher, Daniel M. Michaelson — 2002
• Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinasesTianhua Zhang, Jianfeng Liu, Yao Zhang — 2007
• Progression of Coronary Artery Calcium and Risk of First Myocardial Infarction in Patients Receiving Cholesterol-Lowering TherapyPaolo Raggi, Tracy Q. Callister, Leslee J. Shaw — 2004
• Hepatic Cytochrome P450 Degradation: Mechanistic Diversity of the Cellular Sanitation BrigadeMaria Almira Correia — 2003
• The HMG-CoA Reductase Pathway, Statins and AngiopreventionChong Feng, Anjia Han, Caisheng Ye — 2006
• Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liverMaria Almira Correia, Mingxiang Liao — 2007
• Proteolysis and sterol regulation.Randolph Y. Hampton — 2002
• Apomine, a Novel Hypocholesterolemic Agent, Accelerates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase and Stimulates Low Density Lipoprotein Receptor Activity*Joseph Roitelman, Danièle Masson, Rachel Avner — 2004

Related papers

• Influence of Age and Gender on the Plasma Profiles of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitory Activity Following Multiple Doses of Lovastatin and SimvastatinHaiyung Cheng, John Rogers, Anna E Sweany — 1992
• Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats.Shoji YAMAUCHI, W. G. Linscheer, David Beach — 1991
• Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase.Louis Cohen, Arlène Van Vliet, Loes Roodenburg — 1993
• Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative.Eve E. Slater, J. S. Macdonald — 1988
• Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.Toru Kita, Michael S. Brown, Joseph L. Goldstein — 1980
• Cholesterol Homeostasis in Mononuclear Leukocytes from Patients with Familial Hypercholesterolemia Treated with LovastatinF. C. Hagemenas, D. Roger Illingworth — 1989
• Cholesterol homeostasis in mononuclear leukocytes from patients with familial hypercholesterolemia treated with lovastatin.F CHagemenas, D RIllingworth — 1989
• 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors unmask cryptic regulatory mechanisms.Dayami Lopez, Christopher M. Chambers, Gene C. Ness — 1997
• 3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts.Akira Honda, Gerald Salen, Megumi Honda — 2000