Wnt signaling in cancer
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Summary
Current insights into novel components of Wnt pathways are reviewed and how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control are described.
- Type
- review
- Published
- 2016-09-12
- Cited by
- 1,760
- References
- 219
- Access
- Open access
- OpenAlex
- https://openalex.org/W2520632143
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15277711
Keywords
Wnt signaling pathway, Biology, Carcinogenesis, Cancer, Cancer research
References
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- Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.
- Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells
- Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
- Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
- New insights into the mechanism of Wnt signaling pathway activation.
- beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.
- Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models
- Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
- RNA-Seq of Single Prostate CTCs Implicates Noncanonical Wnt Signaling in Antiandrogen Resistance
- Prospective derivation of a Living Organoid Biobank of colorectal cancer patients
- Multilevel Modelling with Spatial Interaction Effects with Application to an Emerging Land Market in Beijing, China
- Wnt addiction of genetically defined cancers reversed by PORCN inhibition
- The Consensus Molecular Subtypes of Colorectal Cancer
- WNT/PCP signaling pathway and human cancer (review).
- Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links
- The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.
- Association of the APC tumor suppressor protein with catenins.
- Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.
- Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
Cited by
- DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin.
- WNT7A/B promote choroidal neovascularization
- MiR-361-5p inhibits the mobility of gastric cancer cells through suppressing epithelial-mesenchymal transition via the Wnt/β-catenin pathway.
- Antagonistic role of Klotho-derived peptides dynamics in the pancreatic cancer treatment through obstructing WNT-1 and Frizzled binding.
- In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.
- Human colon organoids reveal distinct physiologic and oncogenic Wnt responses
- Gelatin positively regulates the immunosuppressive capabilities of adipose-derived mesenchymal stem cells.
- Inflammatory auxo-action in the stem cell division theory of cancer
- IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance
- Assessment Of Plasma B-Catenin Concentration As Biomarker Of Thyroid Cancer.
- Genes involved in the WNT and vesicular trafficking pathways are associated with melanoma predisposition
- Coordinate regulation of the WNT and Hippo pathways by the novel Ras effector NORE1A.
- Identification of biomarkers for development of NF1-associated malignant peripheral nerve sheath tumours
- Expression patterns of Wnt signaling component, secreted frizzled-related protein 3 in astrocytoma and glioblastoma
- Low expression of secreted frizzled-related protein 2 and nuclear accumulation of β-catenin in aggressive nonfunctioning pituitary adenoma.
- Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
- Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry
- MicroRNA-520e suppresses non-small-cell lung cancer cell growth by targeting Zbtb7a-mediated Wnt signaling pathway.
- Towards an Integrated Map of Genetic Interactions in Cancer Cells
- Wntless promotes bladder cancer growth and acts synergistically as a molecular target in combination with cisplatin.
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