In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.
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Summary
It is suggested that ITGA5-targeting nanoparticles may provide a facil and unique strategy of specially attenuating β-catenin in vivo for treating metastatic TNBC, a potent anti-cancer compound but with short half-life.
- Type
- article
- Published
- 2019-01-01
- Cited by
- 96
- References
- 55
- OpenAlex
- https://openalex.org/W30352320
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53026099
Keywords
Humanities, Philosophy
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Cited by
- Applications of Nanoparticles in Biomedical Imaging
- Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment
- Integrin α9 depletion promotes β-catenin degradation to suppress triple negative breast cancer tumor growth and metastasis
- Ligand‐Installed Nanocarriers toward Precision Therapy
- Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway
- The Clinical Significance of PPEF1 as a Promising Biomarker and Its Potential Mechanism in Breast Cancer
- Tumor Microenvironment: Challenges and Opportunities in Targeting Metastasis of Triple Negative Breast Cancer.
- Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression
- Influence of miR-155 on behaviors of depression mice through regulating Wnt/β-catenin signaling pathway.
- High cytotoxic activity of ZnO@leucovorin nanocomposite based materials against an MCF-7 cell model
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- Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
- SNHG3 silencing suppresses the malignant development of triple-negative breast cancer cells by regulating miRNA-326/integrin α5 axis and inactivating Vav2/Rac1 signaling pathway.
- The progress and perspective of nanoparticle-enabled tumor metastasis treatment
- Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis
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- Recent advances in drug delivery systems for targeting cancer stem cells
- Nanoparticle-delivered miriplatin ultrasmall dots suppress triple negative breast cancer lung metastasis by targeting circulating tumor cells.
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