IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells
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Summary
It is shown that the pleiotropic cytokine interleukin-13 (IL-13) could induce an aggressive phenotype displaying EMT by enhancing the expression of EMT-promoting factor ZEB1 and the STAT6 signaling inhibitor and STAT6 knockdown significantly reversed IL-13-induced EMT and Z EB1 induction in CRC cells.
- Type
- article
- Published
- 2016-08-13
- Cited by
- 91
- References
- 81
- Access
- Open access
- OpenAlex
- https://openalex.org/W2511728014
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4337870
Keywords
Epithelial–mesenchymal transition, Colorectal cancer, Cancer research, Metastasis, Cancer
References
- LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis
- Epithelial-mesenchymal transition in colorectal cancer metastasis: A system review.
- COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING
- Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion
- Targeting the IL‐4/IL‐13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs
- Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients
- Salivary Immunosuppressive Cytokines IL-10 and IL-13 Are Significantly Elevated in Oral Squamous Cell Carcinoma Patients
- JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis.
- Epithelial-mesenchymal transitions in development and disease.
- E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
- Epidemiology and Management of Liver Metastases From Colorectal Cancer
- Differential Macrophage Programming in the Tumor Microenvironment
- The Role of Interleukin 13 in Classical Hodgkin Lymphoma
- Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis.
- CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion.
- Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines.
- STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
- Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells
- STAT6 Activation in Ulcerative Colitis: A New Target for Prevention of IL-13-Induced Colon Epithelial Cell Dysfunction
- Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression
Cited by
- An MSN-PEG-IP drug delivery system and IL13Rα2 as targeted therapy for glioma.
- SOCS molecules: the growing players in macrophage polarization and function
- Molecular signatures linked to stemness and tumorigenesis in tumorspheres from in vitro transformed cells
- Chlamydia Spreading from the Genital to Gastrointestinal Tracts —A Two-Hit Hypothesis
- Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models
- Role of Monoamine oxidase A (MAO-A) in cancer progression and metastasis
- Propofol prevents IL‐13‐induced epithelial–mesenchymal transition in human colorectal cancer cells
- The JAK2 pathway is activated in idiopathic pulmonary fibrosis
- E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells
- Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13–stimulated monocytes and A549 lung carcinoma cells
- Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis
- STAT6 mRNA and protein knockdown using multiple siRNA sequences inhibits proliferation and induces apoptosis of the human colon adenocarcinoma cell line, HT-29
- Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition
- IL-13 Contributes to Drug Resistance of NK/T-Cell Lymphoma Cells by Regulating ABCC4
- Anti-inflammatory cytokines in endometriosis
- Latent Cytomegalovirus Infection in Female Mice Increases Breast Cancer Metastasis
- STAT6 knockdown using multiple siRNA sequences inhibits proliferation and induces apoptosis of human colorectal and breast cancer cell lines
- Clinical implications of STAT6 mRNA and protein knockdown in human colon adenocarcinoma cell line, HT-29
- Chronically stimulated human MAIT cells are unexpectedly potent IL‐13 producers
- Five Novel Genes Related to the Pathogenesis and Progression of Pancreatic Neuroendocrine Tumors by Bioinformatics Analysis With RT-qPCR Verification
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