LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis
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Summary
Results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPARγ axis.
- Type
- article
- Published
- 2015-04-15
- Cited by
- 56
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W25873311
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7706245
Keywords
Concentrator, Photovoltaic system, Solar cell, Sunlight, Photovoltaics
References
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- Conditional gene targeting in macrophages and granulocytes using LysMcre mice
- LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease
- Inflammatory Resolution: new opportunities for drug discovery
- Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
- Antidiabetic Phospholipid – Nuclear Receptor Complex Reveals the Mechanism for Phospholipid Driven Gene Regulation
- 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?
- Liver receptor homolog-1, an emerging metabolic modulator.
- STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells
- Modulation of cytochrome-derived epoxyeicosatrienoic acids pathway: a promising pharmacological approach to prevent endothelial dysfunction in cardiovascular diseases?
- IL‐13 induces expression of CD36 in human monocytes through PPARγ activation
- Contact sensitizers modulate the arachidonic acid metabolism of PMA-differentiated U-937 monocytic cells activated by LPS.
- Antidiabetic actions of a phosphatidylcholine ligand for nuclear receptor LRH-1
- PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13.
- Interleukin-1 Receptor Antagonist Induction as an Additional Mechanism for Liver Receptor Homolog-1 to Negatively Regulate the Hepatic Acute Phase Response*
- Liver Receptor Homolog 1 Is a Negative Regulator of the Hepatic Acute-Phase Response
- LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.
- Memory, Visual Discrimination Performance, and the Human Hippocampus
Cited by
- IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells
- Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor γ-dependent macrophage differentiation
- Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions
- Expression of Liver Receptor Homolog-1 (LRH-1) in Villi and Decidua of Patients with Unexplained Recurrent Spontaneous Abortion
- Immune-regulation and -functions of eicosanoid lipid mediators
- Arginine methylation regulates c-Myc–dependent transcription by altering promoter recruitment of the acetyltransferase p300
- P17, an Original Host Defense Peptide from Ant Venom, Promotes Antifungal Activities of Macrophages through the Induction of C-Type Lectin Receptors Dependent on LTB4-Mediated PPARγ Activation
- Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up‐regulation of dectin‐1 mediated by heme oxygenase‐1‐derived carbon monoxide
- A New Method for Reactivating and Expanding T Cells Specific for Rhizopus oryzae
- LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
- Cholesterol signaling in single cells: lessons from STAR and sm-FISH
- Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease
- IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells
- LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis
- Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients
- Comprehensive analysis of differentially expressed profiles of long non-coding RNAs and messenger RNAs in kaolin-induced hydrocephalus.
- Macrophage nuclear receptors: Emerging key players in infectious diseases
- Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape
- The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions
- Estudio de la regulación de la vía esteroidogénica intestinal y su caracterización en pacientes con colitis ulcerosa
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