Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
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Summary
A computational approach to study tumor-infiltrating immune cells and their interactions with cancer cells is developed and it is found that melanomas expressing high levels of CTLA4 separate into two distinct groups with respect to CD8 T-cell infiltration, which might influence clinical responses to anti-CTLA4 agents.
- Type
- article
- Published
- 2016-08-22
- Cited by
- 2,026
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2507880739
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:548067
Keywords
Biology, Immune system, Immunotherapy, Cancer immunotherapy, Immune checkpoint
References
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- Integrative analysis identifies DNMTs against immune-infiltrating neutrophils and dendritic cells in colorectal cancer
- Prognostic Value and Therapeutic Potential of CBX Family Members in Ovarian Cancer
- Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
- Digitally deconvolving the tumor microenvironment
- Applications of Immunogenomics to Cancer
- Characteristics of lymphocyte-infiltrating papillary thyroid cancer
- xCell: digitally portraying the tissue cellular heterogeneity landscape
- Rôle des calpaïnes dans le vieillissement et la réponse anti-tumorale
- Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data
- Intratumoural Epigenetic Heterogeneity in Early Invasive Colorectal Cancer: A Prognostic Imprint?
- PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients
- Heavy Metal Enlightens Tumor Immunity
- Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells
- Benchmarking: contexts and details matter
- Data normalization considerations for digital tumor dissection
- Revisit linear regression-based deconvolution methods for tumor gene expression data
- New PD-L1 inhibitors in non-small cell lung cancer – impact of atezolizumab
- Immune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma
- Host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity
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