Akt: A Therapeutic Target in Hepatic Ischemia–Reperfusion Injury
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Summary
Four principal methods that reduce I/R injury include hepatic pre- and postconditioning, pharmacological intervention and future miRNA/gene therapy, which has resulted in predictable reduction in hepatocyte damage using the previously mentioned measurements.
- Type
- review
- Published
- 2017-01-02
- Cited by
- 26
- References
- 81
- OpenAlex
- https://openalex.org/W2499096545
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44373422
Keywords
Protein kinase B, Medicine, Liver transplantation, PI3K/AKT/mTOR pathway, Transplantation
References
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- Ischemia/Reperfusion Injury in Liver Surgery and Transplantation
- The p70S6K signalling pathway: a novel signalling system involved in growth regulation.
- Postkonditionierung: ein kurzer Überblick
- Resolvin D1 protects against hepatic ischemia/reperfusion injury in rats.
- The mechanisms and strategies to protect from hepatic ischemia-reperfusion injury.
- NITRIC OXIDE IN LIVER DISEASES
- Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats
- ATF3‐Mediated NRF2/HO‐1 Signaling Regulates TLR4 Innate Immune Responses in Mouse Liver Ischemia/Reperfusion Injury
- Identical MicroRNAs Regulate Liver Protection during Anaesthetic and Ischemic Preconditioning in Rats: An animal study
- PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation.
- MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand*
- Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection
- Carvacrol Alleviates Ischemia Reperfusion Injury by Regulating the PI3K-Akt Pathway in Rats
- Hypoxia-regulated microRNAs in human cancer
- Serum transaminase elevations as indicators of hepatic injury following the administration of drugs.
- Glycogen synthase kinase 3: an emerging therapeutic target.
- Rb1 postconditioning attenuates liver warm ischemia-reperfusion injury through ROS-NO-HIF pathway.
- Ischemic preconditioning of the murine liver protects through the Akt kinase pathway
- The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice
Cited by
- Olprinone protects the liver from ischemia-reperfusion injury through oxidative stress prevention and protein kinase Akt activation.
- Neutrophil extracellular traps in acrolein promoted hepatic ischemia reperfusion injury: Therapeutic potential of NOX2 and p38MAPK inhibitors
- Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury.
- Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver
- Dexmedetomidine protects hepatic cells against oxygen‐glucose deprivation/reperfusion injury via lncRNA CCAT1
- Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies.
- Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF‐κB‐p65/TLR‐4, JAK1/STAT‐3, Nrf‐2, and PI3K/Akt/mTOR Signaling Pathways
- TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway.
- Role of Akt Activation in PARP Inhibitor Resistance in Cancer
- Flavonoids-mediated SIRT1 signaling activation in hepatic disorders.
- Lycopene Alleviates Hepatic Hypoxia/Reoxygenation Injury Through Nrf2/HO-1 Pathway in AML12 Cell
- DUSP12 protects against hepatic ischemia and reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo.
- Hesperidin ameliorates liver ischemia/reperfusion injury via activation of the Akt pathway
- Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies
- Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
- Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury
- Intrathecal morphine pretreatment ameliorated hepatic ischemia-reperfusion injury by reducing inflammation through peripheral and spinal opioid activation in rats
- Low molecular weight NGF mimetic GK‐2 normalizes the parameters of glucose and lipid metabolism and exhibits a hepatoprotective effect on a prediabetes model in obese Wistar rats
- The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review.
- Targeting PI3K/p‐Akt/eNOS, Nrf2/HO‐1, and NF‐κB/p53 signaling pathways by angiotensin 1–7 protects against liver injury induced by ischemia–reperfusion in rats
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