Resolvin D1 protects against hepatic ischemia/reperfusion injury in rats.
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Summary
Administration of RvD1 prior to hepatic I/R attenuates hepatic injury, at least in part through inhibition of inflammatory response and enhancement of phosphorylation of Akt, as demonstrated by attenuations of IL-6, TNF-α and myeloperoxidase levels.
- Type
- article
- Published
- 2015-09-01
- Cited by
- 33
- References
- 29
- OpenAlex
- https://openalex.org/W761234068
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24374003
Keywords
Myeloperoxidase, Medicine, Reperfusion injury, Ischemia, Protein kinase B
References
- The precursor of resolvin D series and aspirin‐triggered resolvin D1 display anti‐hyperalgesic properties in adjuvant‐induced arthritis in rats
- Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti‐nociception
- Resolvin D1 Stimulates Alveolar Fluid Clearance through Alveolar Epithelial Sodium Channel, Na,K-ATPase via ALX/cAMP/PI3K Pathway in Lipopolysaccharide-Induced Acute Lung Injury
- Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis
- The influence of preservation injury on rejection in the hepatic transplant recipient.
- Resolvin D1 and its GPCRs in resolution circuits of inflammation.
- Hyperstimulation With Interleukin 6 Inhibits Cell Cycle Progression After Hepatectomy in Mice
- Estradiol Protects Against Oxygen and Glucose Deprivation in Rat Hippocampal Organotypic Cultures and Activates Akt and Inactivates GSK-3β
- Significance of phosphoinositide 3-kinase pathway on ischemic preconditioning followed by ischemia reperfusion in mice liver.
- Resolvin D1 binds human phagocytes with evidence for proresolving receptors
- Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response
- Factors in the pathophysiology of the liver ischemia-reperfusion injury.
- The acute phase protein response in patients receiving subcutaneous IL‐6
- Resolvins RvE1 and RvD1Attenuate Inflammatory Pain via Central and Peripheral Actions
- Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study
- Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation.
- Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
- Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
- Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
- The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Cited by
- Polyunsaturated fatty acids and inflammation
- The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation.
- Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes
- Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo.
- Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis.
- Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjögren’s Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study
- Akt: A Therapeutic Target in Hepatic Ischemia–Reperfusion Injury
- Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway
- Resolvins as proresolving inflammatory mediators in cardiovascular disease.
- Protective effect of aspirin‐triggered resolvin D1 on hepatic ischemia/reperfusion injury in rats: The role of miR‐146b
- Resolvin D1 attenuates liver ischaemia/reperfusion injury through modulating thioredoxin 2‐mediated mitochondrial quality control
- Roles of Specialized Pro-Resolving Lipid Mediators in Cerebral Ischemia Reperfusion Injury
- RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats
- n-3 PUFAs reduce tumor load and improve survival in a NASH-tumor mouse model
- Resolvin D1 Improves Post-Resuscitation Cardiac and Cerebral Outcomes in a Porcine Model of Cardiac Arrest.
- Specialized pro-resolving lipid mediators in cardiovascular disease, diagnosis, and therapy
- β-Arrestin-2 attenuates hepatic ischemia-reperfusion injury by activating PI3K/Akt signaling
- Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression
- Beneficial effects of natural compounds on experimental liver ischemia-reperfusion injury.
- Resolvin D1 attenuates acid-induced DNA damage in esophageal epithelial cells and rat models of acid reflux.
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