Enhancer regions show high histone H3.3 turnover that changes during differentiation
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Summary
Time-ChIP measurement of histone turnover shows that active enhancers are unusually dynamic in ESCs and changes in highly dynamic nucleosomes predominate at enhancers during differentiation, showing that high turnover could be used to identify regions involved in gene regulation.
- Type
- article
- Published
- 2016-06-15
- Cited by
- 93
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2422776163
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:263966532
Keywords
Enhancer, Histone, Nucleosome, Chromatin, Biology
References
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Cited by
- Histone variants on the move: substrates for chromatin dynamics
- Immune disease-associated variants in gene enhancers point to BET epigenetic mechanisms for therapeutic intervention.
- H3K27me3-mediated silencing of Wilms Tumor 1 supports the proliferation of brain tumor cells harboring the H3.3K27M mutation
- Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity
- Understanding nucleosome dynamics and their links to gene expression and DNA replication
- Resetting the yeast epigenome with human nucleosomes
- Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis.
- A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells
- Software for rapid time dependent ChIP-sequencing analysis (TDCA)
- Polycomb repressive complex 1 defines the nucleosome landscape but not accessibility at target genes
- H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers
- Methods for chemical mapping of O-GlcNAc in the Drosophila genome
- time-ChIP: A Method to Determine Long-Term Locus-Specific Nucleosome Inheritance.
- SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility
- Mitogen and stress- activated protein kinase regulated gene expression in cancer cells.
- Challenges and guidelines toward 4D nucleome data and model standards
- Chromatin plasticity: A versatile landscape that underlies cell fate and identity
- Differential cell fates of muscle stem cells are accompanied by symmetric segregation of canonical H3 histones in vivo
- Chromatin accessibility and the regulatory epigenome
- Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation
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