A natural vaccine candidate strain against cholera.
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Summary
Active immunization of rabbits with strain IEM101 elicited good protection against challenge with virulent strains of V. cholerae O1 and oral administration caused no side effects in 15 human volunteers, colonized the gut for four to ten days and eliciting good immune responses.
- Type
- article
- Published
- 1995-12-01
- Cited by
- 7
- References
- 0
- OpenAlex
- https://openalex.org/W2409295924
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27125311
Keywords
Microbiology, Vibrio cholerae, Pilus, Cholera toxin, Cholera
References
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Cited by
- Construction and Evaluation of a Safe, Live, Oral Vibrio cholerae Vaccine Candidate, IEM108
- Sequence polymorphisms of rfbT among the Vibrio cholerae O1 strains in the Ogawa and Inaba serotype shifts
- IEM101, a naturally attenuated Vibrio cholerae strain as carrier for genetically detoxified derivatives of cholera toxin.
- An Environmental Escherichia albertii Strain, DM104, Induces Protective Immunity to Shigella dysenteriae in Guinea Pig Eye Model
- In Vivo Expression and Immunoadjuvancy of a Mutant of Heat-Labile Enterotoxin of Escherichia coli in Vaccine and Vector Strains of Vibrio cholerae
- Genetic Diversity of Toxigenic and Nontoxigenic Vibrio cholerae Serogroups O1 and O139 Revealed by Array-Based Comparative Genomic Hybridization
- A Recombinant Live Attenuated Strain of Vibrio cholerae Induces Immunity against Tetanus Toxin andBordetella pertussis Tracheal Colonization Factor
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