IEM101, a naturally attenuated Vibrio cholerae strain as carrier for genetically detoxified derivatives of cholera toxin.
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Summary
IEM101, a naturally attenuated Vibrio strain known to be safe and immunogenic in humans, can be engineered to express immunogenic levels of CTK63, and may represent a good candidate for vaccination against cholera.
- Type
- article
- Published
- 2000-08-15
- Cited by
- 22
- References
- 46
- OpenAlex
- https://openalex.org/W2040737833
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44853191
Keywords
Vibrio cholerae, Cholera toxin, Microbiology, Bacteria, Biology
References
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- Enterotoxicity of Bacteria-free Culture-filtrate of Vibrio cholerae
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Cited by
- Construction and Evaluation of a Safe, Live, Oral Vibrio cholerae Vaccine Candidate, IEM108
- Resistance of the cholera vaccine candidate IEM108 against CTXPhi infection.
- The burden of cholera
- Use of stabilized luciferase-expressing plasmids to examine in vivo-induced promoters in the Vibrio cholerae vaccine strain CVD103-HgR
- Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
- Investigation into immunological responses against a native recombinant CTB whole‐cell Vibrio cholerae vaccine in a rabbit model
- Construction and characterization of an auxotrophic ctxA mutant of O139 Vibrio cholerae.
- Construction and characterization of a thyA mutant derived from cholera vaccine candidate IEM101
- Exploiting cholera vaccines as a versatile antigen delivery platform
- The hows and whys of constructing a native recombinant cholera vaccine
- The Use of Live Attenuated Bacteria as a Delivery System for Heterologous Antigens
- A Single Point Mutation within the Coding Sequence of Cholera Toxin B Subunit Will Increase Its Expression Yield
- Comparison of a Regulated Delayed Antigen Synthesis System with In Vivo-Inducible Promoters for Antigen Delivery by Live Attenuated Salmonella Vaccines
- Differential expression of receptors for Shiga and Cholera toxin is regulated by the cell cycle.
- Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria
- Immunoenhancing effects of a new probiotic strain, Lactobacillus fermentum PL9005.
- Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform
- Chapter 56 – Antigen Delivery Systems II: Development of Live Recombinant Attenuated Bacterial Antigen and DNA Vaccine Delivery Vector Vaccines
- Toxin-Based Mucosal Adjuvants
- Construction and Evaluation of a Safe , Live , Oral Vibrio cholerae Vaccine Candidate , IEM 108
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