Fundamentals of cancer metabolism
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Summary
A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.
- Type
- review
- Published
- 2016-05-01
- Cited by
- 2,613
- References
- 215
- Access
- Open access
- OpenAlex
- https://openalex.org/W2395626624
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40543560
Keywords
Cancer, Computer science, Computational biology, Data science, Cognitive science
References
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- Targeting SOD1 reduces experimental non–small-cell lung cancer.
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- Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
- Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
- Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
- The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
- MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
- Dietary control of lipogenesis in vivo in host tissues and tumors of mice bearing Ehrlich ascites carcinoma.
- The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
- Suppressors of superoxide production from mitochondrial complex III
- p53 in survival, death and metabolic health: a lifeguard with a licence to kill
- Hypoxia-mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
- Hypoxia Induces Production of L-2-Hydroxyglutarate
- An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
- Extracellular Metabolic Energetics Can Promote Cancer Progression
- Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
- A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels
- Modulation of oxidative stress as an anticancer strategy
- Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
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- Metabolic Plasticity of Stem Cells and Macrophages in Cancer
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- 3-Chloro-N′-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy
- Environmental Sciences: Book Review
- Metabolomic profiling for early cancer detection: current status and future prospects
- Blocking fatty acid synthesis reduces lung tumor growth in mice
- Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
- On mitochondrial metabolism in tumor biology
- ROS homeostasis and metabolism: a critical liaison for cancer therapy
- The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer
- Role of Oncogenes and Tumor Suppressors in Metabolic Reprogramming and Cancer Therapeutics: A Review
- Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension
- The role of metabolomics in precision medicine
- Tumour microenvironment factors shaping the cancer metabolism landscape
- Multicellular Spheroids as a Model for Hypoxia-induced EMT.
- Glioma: experimental models and reality
- PFKFB3, a direct target of p63, is required for proliferation and inhibits differentiation in epidermal keratinocytes
- Exo-MFA – A 13C metabolic flux analysis to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism
- A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.
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