Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response*
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Summary
The uncharacterized zinc finger protein Tmc1 is identified as a dynamically regulated stress-responsive protein that represents a novel effector and substrate of the Rpn4 proteotoxic stress response.
- Type
- article
- Published
- 2016-05-12
- Cited by
- 13
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2391743628
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13737222
Keywords
Proteostasis, Proteasome, Cell biology, Transcription factor, Effector
References
- A Conserved Protein with AN1 Zinc Finger and Ubiquitin-like Domains Modulates Cdc48 (p97) Function in the Ubiquitin-Proteasome Pathway*
- Ubiquitin‐conjugating enzymes UBC4 and UBC5 mediate selective degradation of short‐lived and abnormal proteins.
- Proteostasis impairment in protein-misfolding and -aggregation diseases.
- Proteasomal Degradation of RPN4 via Two Distinct Mechanisms, Ubiquitin-dependent and -independent*
- Genome-Wide Analysis Identifies MYND-Domain Protein Mub1 as an Essential Factor for Rpn4 Ubiquitylation
- Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast
- Resistance to cadmium mediated by ubiquitin-dependent proteolysis
- Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop.
- Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.
- Rpn4 Is a Physiological Substrate of the Ubr2 Ubiquitin Ligase*
- The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses.
- Cuz1/Ynl155w, a Zinc-dependent Ubiquitin-binding Protein, Protects Cells from Metalloid-induced Proteotoxicity*
- Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts.
- Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells.
- Identification of F‐box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae
- Dual Function of eIF3j/Hcr1p in Processing 20 S Pre-rRNA and Translation Initiation*
- A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
- The Ubiquitin–Proteasome System of Saccharomyces cerevisiae
- Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast
- Molecular Architecture and Assembly of the Eukaryotic Proteasome
Cited by
- Phospholipase Lpl1 links lipid droplet function with quality control protein degradation
- Induction of Proteotoxic Stress by the Mycotoxin Patulin
- Investigation of butanol tolerance in Saccharomyces cerevisiae and of genes linked to butanol tolerance
- Deregulation of the 19S proteasome complex increases yeast resistance to 4‐NQO and oxidative stress via upregulation of Rpn4‐ and proteasome‐dependent stress responsive genes
- Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity
- Regulation of the Unfolded Protein Response in Yeast by Oxidative Stress
- Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response
- Thiol-based direct threat sensing by the stress-activated protein kinase Hog1
- Reg1 and Snf1 Regulate Stress-Induced Relocalization of Protein Phosphatase-1 to Cytoplasmic Granules
- Yeast PI31 Inhibits the Proteasome by a Direct Multisite Mechanism
- Mechanosensitive Ion Channels and Their Role in Cancer Cells
- Structure of the Preholoproteasome Reveals Late Steps in Proteasome Core Particle Biogenesis
- Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony
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