Analysis of shared heritability in common disorders of the brain
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Summary
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
- Type
- article
- Published
- 2018-06-22
- Cited by
- 1,842
- References
- 91
- Access
- Open access
- OpenAlex
- https://openalex.org/W2340656051
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8568080
Keywords
Heritability, Genome-wide association study, Missing heritability problem, Etiology, Genetic association
References
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Cited by
- Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers
- Bridging the Great Divide: What Can Neurology Learn from Psychiatry?
- Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls.
- New insights on synaptic dysfunction in neuropsychiatric disorders.
- Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings
- Tics and Tourette Syndrome.
- Gilles de la Tourette syndrome
- The Genetics of Gilles de la Tourette Syndrome: a Common Aetiological Basis with Comorbid Disorders?
- Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis
- Genetic Variability in Both the Adaptive and Innate Immune Systems Contribute to Alzheimer's and Parkinson's Disease Risk
- Cross-disorder analysis of schizophrenia and 19 immune diseases reveals genetic correlation
- Genetic correlations among neuro-behavioral and immune-related phenotypes based on genome-wide association data
- The implications of the shared genetics of psychiatric disorders
- Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease
- Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations
- Pathways analyses of schizophrenia GWAS focusing on known and novel drug targets
- Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study.
- Genetics and educational attainment
- Gene-Environment Interplay in Depressive Symptoms: Moderation by Age, Sex, and Physical Illness
- A Commentary on Maes et al. "A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents".
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