Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells.
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Summary
The data suggest that troglitazone enhances glucose uptake through GLUT1 with an acceleration of glycolysis, and improves the abnormal intracellular glucose metabolism under high-glucose conditions in rat mesangial cells.
- Type
- article
- Published
- 2000-03-01
- Cited by
- 15
- References
- 28
- OpenAlex
- https://openalex.org/W10726906
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20714085
Keywords
Frontier, Terminology, Constructive, Ecological niche, Niche
References
- How does hyperglycaemia predispose to diabetic nephropathy?
- Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats
- Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype.
- Diabetes-induced glomerular dysfunction: links to a more reduced cytosolic ratio of NADH/NAD+.
- Troglitazone inhibits angiotensin II‐induced DNA synthesis and migration in vascular smooth muscle cells
- Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes.
- CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes.
- Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects
- Aldose reductase inhibitor prevents hyperproliferation and hypertrophy of cultured rat vascular smooth muscle cells induced by high glucose.
- Effect of High Glucose on Type IV Collagen Production by Cultured Glomerular Epithelial, Endothelial, and Mesangial Cells
- Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats.
- In vitro studies on the action of CS-045, a new antidiabetic agent.
- Troglitazone enhances glucose uptake and inhibits mitogen-activated protein kinase in human aortic smooth muscle cells.
- Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats.
- Normalization of glucose entry under the high glucose condition by phlorizin attenuates the high glucose-induced morphological and functional changes of cultured bovine retinal pericytes.
- Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL KsJ-db db mice
- Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes.
- Synthesis of Type VI Collagen by Cultured Glomerular Cells and Comparison of Its Regulation by Glucose and Other Factors With That of Type IV Collagen
- Antidiabetic agent pioglitazone increases insulin receptors on 3T3‐L1 adipocytes
- The uncoupling proteins, a review.
Cited by
- Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation.
- Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study
- Carcinogenic susceptibility of rasH2 mice to troglitazone
- Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis.
- Troglitazone Inhibits Isolated Cell Proliferation, and Induces Apoptosis in Isolated Rat Mesangial Cells
- Defective P2Y purinergic receptor function: A possible novel mechanism for impaired glucose transport
- The cellular fate of glucose and its relevance in type 2 diabetes.
- Troglitazone Stimulates Cancer Cell Uptake of 18F-FDG by Suppressing Mitochondrial Respiration and Augments Sensitivity to Glucose Restriction
- Lessons from the Trials for the Desirable Effects of Sodium Glucose Co-Transporter 2 Inhibitors on Diabetic Cardiovascular Events and Renal Dysfunction
- Metabolic reprogramming: A novel therapeutic target in diabetic kidney disease
- Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications
- The troglitazone derivative EP13 disrupts energy metabolism through respiratory chain complex I inhibition in breast cancer cells and potentiates the antiproliferative effect of glycolysis inhibitors
- Overload of Glucose Metabolism as Initiating Factor in Diabetic Embryopathy and Prevention by Glyoxalase 1 Inducer Dietary Supplement
- The New Enclosures: Critical Perspectives on Corporate Land Deals
- Altered Glucose Transport and Its Metabolic Effects in Glomerular Cells
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