Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins

Keywords

Medicine, Meta-analysis, Internal medicine

References

• Statin‐associated myopathyIan Hamilton‐Craig — 2001
• Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group — 1998
• Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12064 myocardial infarction survivors.SEARCH Study Collaborative Group — 2007
• The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts.The Post Coronary Artery Bypass Graft Trial Investigators — 1997
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.S. Féasson — 2002
• Lovastatin and beyond: the history of the HMG-CoA reductase inhibitorsJonathan A. Tobert — 2003
• Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT).The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group, The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group — 2002
• MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial.Rory Collins, Jane Armitage, Sarah Parish — 2003
• The Association between Cholesterol and Death from InjuryP Cummings, Bruce M. Psaty — 1994
• Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials.Matthew F. Muldoon, Stephen B. Manuck, Karen A. Matthews — 1990
• Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.Helen M. Colhoun, D. J. Betteridge, Paul N. Durrington — 2004
• Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention TrialJeremiah Stamler, Olga Vaccaro, James D. Neaton — 1993
• Assessing possible hazards of reducing serum cholesterolM R Law, Simon G. Thompson, Nicholas Wald — 1994
• The liver and lovastatin.Keith G. Tolman — 2002
• Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial.Gary C Brown — 2004
• Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations.Zhengming Chen, Richard Peto, Rory Collins — 1991
• Effect of greater LDL-C reductions on prognosis-the incremental decrease in endpoints through aggressive lipid lowering (IDEAL) trialTerje R. Pedersen, Ole Færgeman, Ingar Holme — 1999
• Statins and prostate cancer risk: a case-control study.Jackilen Shannon, Selome Tewoderos, Mark Garzotto — 2005
• Low serum cholesterol and the risk of cancer: an analysis of the published prospective studiesM R Law, Simon G. Thompson — 1991
• Report of the Conference on Low Blood Cholesterol: Mortality AssociationsDavid R. Jacobs, H Blackburn, M W Higgins — 1992

Cited by

• Putting results of a clinical trial into perspectiveNicholas Wilcken, Val Gebski, Rhana Pike — 2007
• Prescribed Daily Doses (PDDs) of Hypolipidaemic Agents in South Africa with Emphasis on HMG CoA Reductase InhibitorsIlse Truter — 2014
• [Achievement of therapeutic target in subjects on statin treatment in clinical practice. Results of the STAR (Statins Target Assessment in Real practice) study].Luca Degli Esposti, Diego Sangiorgi, Marcello Arca — 2011
• JUPITER: e adesso?Gian Piero Perna — 2009
• The case for treating hypercholesterolemia at an earlier age: moving toward consensus.Daniel Steinberg, Scott M. Grundy — 2012
• Hochdosierte Statintherapie für kardiovaskuläre RisikopatientenChristoph H. Saely, Heinz Drexel, Kurt Huber — 2010
• Bedeutung der Lipidtherapie bei DiabetesChristoph H. Saely, Heinz Drexel — 2010
• The CEPHEUS Pan-Asian survey: high low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre.Raymond Hon-Wah Chan, Pang-Fai Chan, Kelvin Chan — 2012
• Statins: another class of antihypertensive agents?Haralampos Milionis, Evangelos Liberopoulos, A. Achimastos — 2006
• Drugs and the fetusJ. A. Stricker, Mohammad Rahmani, Alan W. Hodges — 2006
• Diabetes guidelines: easier to preach than to practise?심정환, 서광석, 이영은 — 2006
• Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort studyGonzalo Rodríguez Prada — 2006
• Impact of Carotid Endarterectomy on Medical Secondary Prevention After a Stroke or a Transient Ischemic Attack: Results from the Reduction of Atherothrombosis for Continued Health (REACH) RegistryRomán de la Calle — 2006
• Effects of atorvastatin and simvastatin on atrial plateau currents.金子良平, 田部耕ANGELO, 渡辺聖文 — 2007
• Management of coronary artery disease in patients with type 2 diabetes mellitusBruce D. Jones — 2007
• Targets – who needs them? Success with statin therapiesД. Н. Попов, Н. Г. Сосновский, М. В. Сиухин — 2007
• Cholesterol reduction yields clinical benefits: meta-analysis including recent trials.Pamela Patterson Pugliese, Donald R. Chipley — 2007
• Effect of intensive lipid-lowering therapy on mortality after acute coronary syndrome (a patient-level analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trials).Antonio Mendoza Fillola, Pedro César Cerrillo Torremocha — 2007
• Cardiovascular risk factors and their management in 1282 adult people with type 1 diabetesDaniel Strickland, Jacques Colange, P. G. Shaw — 2007
• Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe–statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemiaValérie Courtin-Chabre — 2008

Related papers

• Genentech taps Affimed’s antibodiesRyan Cross — 2018
• KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIKDjayanti Sari — 2023
• Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoriaAbraham Dib, Luiz Bóro Puig, Décio Salvadori — 1988
• Cardiac retransplantation in children.Kirk R. Kanter, Robert Vincent, Alexandria M. Berg — 2004
• PD-09.06: Third kidney transplants: surgical aspectsA. Rodrı́guez-Antolı́n, M. Díez Blanco, Federico de la Rosa — 2006
• Avaliacao hemodinamica sequencial em transplante de coracaoAngela Fiorelli, Noedir Antônio Groppo Stolf, L F Moreira — 1987
• Thoracoscopic discectomy and fusion in the treatment of spinal deformitiesMehmet Akif Kaygusuz, Mustafa Şahin, İrfan Esenkaya — 1999
• [Hepatic retransplant and acute Budd Chiari syndrome. Case report].Andrés Manuel Savío-López, Evelin E Lara-Molina, Ramón Soliva-Domínguez — 2005