Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans.
Explore this paper's citation graph
Summary
New molecular components of neural G protein signaling mechanisms, including Regulators of G protein Signaling (RGS proteins) that inhibit signaling, a new Gαq effector (the Trio RhoGEF domain), and the RIC-8 protein that is required for neuronal Gα signaling are identified.
- Type
- review
- Published
- 2016-03-03
- Cited by
- 55
- References
- 295
- Access
- Open access
- OpenAlex
- https://openalex.org/W2329055726
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28859293
Keywords
Heterotrimeric G protein, G protein-coupled receptor, G protein, Biology, Gq alpha subunit
References
- Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways*
- Biogenic amine receptors in parasitic nematodes: what can be learned from Caenorhabditis elegans?
- The G-Protein-Coupled Serotonin Receptor SER-1 Regulates Egg Laying and Male Mating Behaviors in Caenorhabditis elegans
- CAPS and Munc13: CATCHRs that SNARE Vesicles
- Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos.
- Neuropeptide gene families in Caenorhabditis elegans.
- Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
- Activation of the cloned muscarinic potassium channel by G protein βγ subunits
- Nonredundant function of two highly homologous octopamine receptors in food‐deprivation‐mediated signaling in Caenorhabditis elegans
- DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation
- Characterization of a tyramine receptor from Caenorhabditis elegans
- Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia.
- Tyramine receptor (SER‐2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans
- Genetic analysis of RGS protein function in Caenorhabditis elegans.
- SER‐7b, a constitutively active Gαs coupled 5‐HT7‐like receptor expressed in the Caenorhabditis elegans M4 pharyngeal motorneuron
- The complete family of genes encoding G proteins of Caenorhabditis elegans
- Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
- A network of G-protein signaling pathways control neuronal activity in C. elegans.
- Insights into RGS protein function from studies in Caenorhabditis elegans.
- Gαs-Induced Neurodegeneration inCaenorhabditis elegans
Cited by
- Neuroendocrine modulation sustains the C. elegans forward motor state
- Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival
- The SEK-1 p38 MAP kinase pathway modulates Gq signaling in C. elegans
- Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans
- The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans
- Impaired Dopamine-Dependent Locomotory Behavior of C. elegans Neuroligin Mutants Depends on the Catechol-O-Methyltransferase COMT-4
- Serotonin Disinhibits a Caenorhabditis elegans Sensory Neuron by Suppressing Ca2+-Dependent Negative Feedback
- Monoamines differentially modulate neuropeptide release from distinct sites within a single neuron pair
- Dopamine negatively modulates the NCA ion channels in C. elegans
- Presynaptic Gαo (GOA-1) signaling depresses command neuron excitability to allow for stretch-dependent modulation of egg-laying behavior in C. elegans
- Genetic behavioral screen identifies an orphan anti-opioid system
- Optical dissection of synaptic plasticity for early adaptation in Caenorhabditis elegans.
- Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit
- Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network
- Sensory regulated Wnt production from neurons helps make organ development robust to environmental changes in C. elegans
- The female-specific VC neurons are mechanically activated, feed-forward motor neurons that facilitate serotonin-induced egg laying in C. elegans
- rab-27 acts in an intestinal secretory pathway to inhibit axon regeneration in C. elegans
- Activation of Microbiota Sensor- Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-Β Induced Neurotoxicity by Modulating Proteolysis/Senescence Axis
- Personalized Perturbation Profiles Reveal Concordance between Autism Blood Transcriptome Datasets
- The neural G protein Gαo tagged with GFP at an internal loop is functional in C. elegans
Related papers
- RGS2-mediated regulation of Gqalpha.
- Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.
- GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.
- Two Chimeric Regulators of G-protein Signaling (RGS) Proteins Differentially Modulate Soybean Heterotrimeric G-protein Cycle*
- Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
- A new family of G-protein regulators - the RGS proteins.
- New dimensions in G protein signalling: G beta 5 and the RGS proteins.
- RGS protein regulation and signaling diversity of protease‐activated receptors (PAR1 and PAR2)