Genome Engineering with TALE and CRISPR Systems in Neuroscience
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Summary
The recent development in genome engineering is discussed and potential applications of this technology in the field of neuroscience are discussed, contributing to the development of novel tools for basic and clinical neuroscience.
- Type
- review
- Published
- 2016-04-06
- Cited by
- 26
- References
- 296
- Access
- Open access
- OpenAlex
- https://openalex.org/W2322616593
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13977534
Keywords
CRISPR, Genome editing, Genome engineering, Effector, Computational biology
References
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- Recent developments and clinical studies utilizing engineered zinc finger nuclease technology
- Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos.
- In vivo genome editing of the albumin locus as a platform for protein replacement therapy.
- Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a
- DNA polymerase ε.
- Role of DNA methylation and the DNA methyltransferases in learning and memory
- Development of an intein-mediated split–Cas9 system for gene therapy
- Involvement of single-stranded tails in homologous recombination of DNA injected into Xenopus laevis oocyte nuclei.
- Continuous directed evolution of DNA-binding proteins to improve TALEN specificity
- How specific is CRISPR/Cas9 really?
- Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases
- A targeted gene knockout in Drosophila.
- Homologous and illegitimate recombination in developing Xenopus oocytes and eggs
Cited by
- Gene Targeting Using Homologous Recombination in Embryonic Stem Cells: The Future for Behavior Genetics?
- Common therapeutic strategies for prion and Alzheimer’s diseases
- Myotonic Dystrophies: State of the Art of New Therapeutic Developments for the CNS
- Gene therapy and editing: Novel potential treatments for neuronal channelopathies
- Biotechnological Advances in Methods for Functional Analysis of Genes
- APP mouse models for Alzheimer's disease preclinical studies
- Temporal variation in brain transcriptome is associated with the expression of female mimicry as a sequential male alternative reproductive tactic in fish
- The Value of Comparative Animal Research: Krogh’s Principle Facilitates Scientific Discoveries
- Genetic tool development and systemic regulation in biosynthetic technology
- Developing genetic tools in Methanococcus maripaludis
- Neurobiology of Resilience: Interface Between Mind and Body
- Gene Editing and Alzheimer's Disease: Is There Light at the End of the Tunnel?
- CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
- Genetic Toolkits to Design and Build Mammalian Synthetic Systems.
- Brain Pathogenesis and Potential Therapeutic Strategies in Myotonic Dystrophy Type 1
- Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention
- Advances in S gene targeted genome-editing and its applicability to disease resistance breeding in selected Solanaceae crop plants
- Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators
- Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Рart II: Overcoming strategies
- Epigenome Editing: Emerging Tools, Therapeutic Applications, and Challenges in Human Disease Treatment
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