Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk.
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Summary
Omics and systems biology studies in nanotoxicology are highlighted, aiming towards the implementation of a systems nanot toxicology and mechanism-based risk assessment of nanomaterials.
- Type
- review
- Published
- 2016-05-15
- Cited by
- 114
- References
- 94
- OpenAlex
- https://openalex.org/W2257458640
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23222403
Keywords
Nanotoxicology, Mechanism (biology), Risk analysis (engineering), Hazard, Systems biology
References
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- Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics.
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- Minimum information about a microarray experiment (MIAME)—toward standards for microarray data
- Bridging the divide between human and environmental nanotoxicology.
- Metabonomics: a platform for studying drug toxicity and gene function
- Progress and future of in vitro models to study translocation of nanoparticles
- Epigenetic mechanisms in nanomaterial-induced toxicity.
- The nanoparticle biomolecule corona: lessons learned - challenge accepted?
- Implementation of Alternative Test Strategies for the Safety Assessment of Engineered Nanomaterials
- Environmental epigenomics and disease susceptibility
- Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles
- Systems Toxicology: From Basic Research to Risk Assessment
- Chronic nanoparticulate silver exposure results in tissue accumulation and transcriptomic changes in zebrafish.
- RNA-Seq: a revolutionary tool for transcriptomics
Cited by
- Key challenges for nanotechnology: Standardization of ecotoxicity testing
- Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead.
- Three Functional Biomarkers for Monitoring the Nanoscale Zero-Valent Iron (nZVI)-Induced Molecular Signature on Soil Organisms
- Epigenetic modulation upon exposure of lung fibroblasts to TiO2 and ZnO nanoparticles: alterations in DNA methylation
- Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.
- A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO)
- Nanotoxicology on the right track : focus on metal and metal oxide nanoparticles
- The changing face of nanomaterials: Risk assessment challenges along the value chain
- Cytotoxic and Proinflammatory Effects of Metal-Based Nanoparticles on THP-1 Monocytes Characterized by Combined Proteomics Approaches.
- Mapping Differential Cellular Protein Response of Mouse Alveolar Epithelial Cells to Multi-Walled Carbon Nanotubes as a Function of Atomic Layer Deposition Coating
- Molecular Mechanisms of Developmental Toxicity Induced by Graphene Oxide at Predicted Environmental Concentrations.
- A comprehensive framework for evaluating the environmental health and safety implications of engineered nanomaterials
- Proteomic Investigation of Various Methods used for Carbon Nanotube Exposure.
- Cerium oxide nanoparticles inhibit differentiation of neural stem cells
- In vitro approaches to assess the hazard of nanomaterials
- Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short‐term inhalation exposure to copper oxide nanoparticles
- Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials
- Nanotoxicology: Assessment of Toxicological Properties of Nanomaterial
- Reprint of "Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead".
- Risk assessment of pesticides in estuaries: a review addressing the persistence of an old problem in complex environments
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