Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.
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Summary
Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas is presented.
- Type
- review
- Published
- 2016-01-12
- Cited by
- 2,030
- References
- 588
- OpenAlex
- https://openalex.org/W2237872262
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206534287
Keywords
Library science, China, Web of science, Chemistry, Political science
References
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- Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl Fluorides
Cited by
- USP14 Inhibitor Attenuates Cerebral Ischemia/Reperfusion-Induced Neuronal Injury in Mice
- A redox-economical synthesis of trifluoromethylated enamides with the Langlois reagent.
- Activation of SF6 at Platinum Complexes: Formation of SF3 Derivatives and Their Application in Deoxyfluorination Reactions.
- Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α-Bromodifluoroacetamides.
- Synthesis of 4-(Trifluoromethyl)cyclopentenones and 2-(Trifluoromethyl)furans by Reductive Trifluoroacetylation of Ynones.
- Visible-light induced three-component alkynyl-difluoroalkylation of unactivated alkenes.
- Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects.
- Organocatalytic C(sp3)-H Functionalization of 5-Methyl-2,3-dihydrofuran Derivatives with Trifluoropyruvates via a Sequential exo-Tautomerization/Carbonyl-Ene Process.
- New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups.
- An Energetic Guide for Estimating Trifluoromethyl Cation Donor Abilities of Electrophilic Trifluoromethylating Reagents: Computations of X-CF3 Bond Heterolytic Dissociation Enthalpies.
- Fluorination of pyrrole derivatives by Selectfluor
- Mechanistic Studies on Intramolecular C-H Trifluoromethoxylation of (Hetero)arenes via OCF3-Migration
- A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity.
- Copper-Catalyzed C(sp(2))-H Difluoroalkylation of Aldehyde Derived Hydrazones with Diboron as Reductant.
- Metal‐Free Direct Dehydroxytrifluoromethylthiolation of Alcohols via the Umpolung Reactivity of Trifluoromethanesulfenamides
- Radical perfluoroalkylation - easy access to 2-perfluoroalkylindol-3-imines via electron catalysis.
- Tailor-Made α-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA)
- Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the π‐Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds
- Multigram Scale Syntheses of First and Second Generation of Trifluoromethanesulfenamide Reagents
- Comprehensive Energetic Scale for Quantitatively Estimating the Fluorinating Potential of N-F Reagents in Electrophilic Fluorinations.
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