Mediator and Cohesin Connect Gene Expression and Chromatin Architecture
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Summary
It is reported that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells.
- Type
- article
- Published
- 2010-08-01
- Cited by
- 1,869
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W2175853567
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4394132
Keywords
Cohesin, Enhancer, Promoter, Biology, Chromatin
References
- Genes and Signals
- Mapping cis- and trans- chromatin interaction networks using Chromosome Conformation Capture (3C)
- Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
- Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.
- Activator-Mediator binding regulates Mediator-cofactor interactions
- A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome
- Condensin and cohesin complexity: the expanding repertoire of functions
- Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
- Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
- Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells*
- An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
- Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.
- Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation
- Role of MED12 in transcription and human behavior.
- Role of integration host factor in the regulation of the glnHp2 promoter of Escherichia coli.
- Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation.
- Cohesinopathies, gene expression, and chromatin organization
- Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
- The human Mediator complex: a versatile, genome-wide regulator of transcription
- Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Cited by
- Chromatin Insulators: Master Regulators of the Eukaryotic Genome
- Genomic approaches for the discovery of CFTR regulatory elements
- DNA stress and strain, in silico, in vitro and in vivo
- A dominant negative over expression model of mammalian MED12 function
- Linking Chromosome Duplication and Segregation via Sister Chromatid Cohesion
- The Epigenetic Paradox of Pluripotent ES Cells.
- Emerging functions of multi-protein complex Mediator with special emphasis on plants
- The three-dimensional genome: regulating gene expression during pluripotency and development
- Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner
- How subtle changes in 3D structure can create large changes in transcription
- The role of HDAC1 and HDAC2 in transcription and induced pluripotency
- Changing Fate: Cellular Reprogramming
- Cohesin subunit RAD21: From biology to disease
- Regulation of Tcra/Tcrd locus conformation during thymocyte development
- Proliferation control in the central nervous system of Drosophila melanogaster
- Telomere and Proximal Sequence Analysis Using High-Throughput Sequencing Reads
- Mediator and its role in non-coding RNA and chromatin regualtion
- Regulation of renin gene expression by CTCF, Nr2f2, Nr2f6, Nr4a1 and maintenance of the renin expressing cell
- Regulatory Elements and Gene Expression in Primates and Diverse Human Cell-types
- Determination of An Interaction between Nipped B-Like Protein and MLL
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