Crystal structure of parallel quadruplexes from human telomeric DNA
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Summary
This crystal structure of a quadruplex formed from four consecutive human telomeric DNA repeats and grown at a K+ concentration that approximates its intracellular concentration suggests a straightforward path for telomere folding and unfolding, as well as ways in which it can recognize telomerre-associated proteins.
- Type
- article
- Published
- 2002-06-20
- Cited by
- 1,856
- References
- 30
- OpenAlex
- https://openalex.org/W2172060739
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4422211
Keywords
Telomere, DNA, G-quadruplex, Guanine, Chemistry
References
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- G-quadruplex DNA: A target for drug design
Cited by
- Processing of Alternative DNA Structures in the Human Telomere
- Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions.
- Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C—H…N bonds
- The structure of telomeric DNA.
- A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions.
- Guanine‐Rich DNA Nanocircles for the Synthesis and Characterization of Long Cytosine‐Rich Telomeric DNAs
- Targeting Telomerase
- G-quadruplexes induce apoptosis in tumor cells.
- A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence
- Guanine quadruplex DNA structure restricts methylation of CpG dinucleotides genome-wide.
- Hemin/G-quadruplexes as DNAzymes for the fluorescent detection of DNA, aptamer-thrombin complexes, and probing the activity of glucose oxidase.
- Hairpins participating in folding of human telomeric sequence quadruplexes studied by standard and T-REMD simulations
- Discovery and Structural Characterization of G-quadruplex DNA in Human Acetyl-CoA Carboxylase Gene Promoters: Its Role in Transcriptional Regulation and as a Therapeutic Target for Human Disease.
- Light-induced oxidation of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin
- Pharmacological strategies to target oncogenic KRAS signaling in pancreatic cancer.
- Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host–guest interactions
- Stabilization vs. destabilization of G-quadruplex superstructures: the role of the porphyrin derivative having spermine arms.
- Binding Modes and Selectivity of Ruthenium Complexes to Human Telomeric DNA G-Quadruplexes.
- Dynamique et régulation des assemblages nucléoprotéiques des télomères humains : Fonctions de la protéine TRF2.
- Assessing DNA structures with 125I radioprobing
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