Vaccines: Effector and memory T-cell differentiation: implications for vaccine development
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Summary
The signals required for commitment to this programme of development and the factors that might influence its progression are discussed and models of the pathways of effector and memory T-cell differentiation are discussed.
- Type
- review
- Published
- 2002-04-01
- Cited by
- 1,763
- References
- 137
- Access
- Open access
- OpenAlex
- https://openalex.org/W2170904230
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:209556129
Keywords
Effector, Biology, Cell biology, CD8, T cell
References
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- Separable effector T cell populations specialized for B cell help or tissue inflammation
- Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
- 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.
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- Response of naïve and memory CD8+ T cells to antigen stimulation in vivo
- Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells
- Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
- CD4+ T cell effectors can become memory cells with high efficiency and without further division
- Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
- Gene Expression in Antigen-Specific CD8+ T Cells During Viral Infection1
- Vaccine Protection Against Functional CTL Abnormalities in Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys1
- A cellular calculus for signal integration by T cells
- IL-7 Administration Alters the CD4:CD8 Ratio, Increases T Cell Numbers, and Increases T Cell Function in the Absence of Activation1
- Lymphocyte traffic control by chemokines
- Cutting edge: antigen-dependent regulation of telomerase activity in murine T cells.
- Regulating T helper cell immunity through antigen responsiveness and calcium entry
- Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
- Modelling T-cell memory by genetic marking of memory T cells in vivo
- Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory
Cited by
- Regulation of memory CD8 T cell differentiation
- Long-Term Maintenance of gp120-Specific Immune Responses by Genetic Vaccination with the HIV-1 Envelope Genes Linked to the Gene Encoding Flt-3 Ligand 1
- HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity
- Vaccine development strategies for improving immunization: the role of modern immunology
- APC-targeted immunization for the treatment of HIV-1
- Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors1
- Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention.
- Memory cytolytic T-lymphocytes: induction, regulation and implications for vaccine design
- Spontaneous Recovery in Acute Human Hepatitis C Virus Infection: Functional T-Cell Thresholds and Relative Importance of CD4 Help
- Antigen kinetics determines immune reactivity
- Killer T cells in influenza.
- Anthrax protective antigen administered by DNA vaccination to distinct subcellular locations potentiates humoral and cellular immune responses
- Temporal Regulation of Rapamycin on Memory CTL Programming by IL-12
- The Role of OX40 (CD134) in T-Cell Memory Generation
- The LCMV gp33-specific memory T cell repertoire narrows with age
- Sustained and incomplete recovery of naïve CD8+ T-cell precursors after sepsis contributes to impaired CD8+ T-cell responses to infection
- High viral burden restricts short-lived effector cell (SLEC) number at late times postinfection through increased nTreg expansion
- Merkel polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers
- Combinatorial Immunotherapy of Polyinosinic-Polycytidylic Acid and Blockade of Programmed Death-1 Induces Effective CD8 T Cell Responses against Established Tumors
- Memory CD4 T cells in Influenza
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