Focal adhesions, contractility, and signaling.
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Summary
Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture and are regions of signal transduction that relate to growth control.
- Type
- review
- Published
- 1996-11-01
- Cited by
- 1,998
- References
- 407
- Access
- Open access
- OpenAlex
- https://openalex.org/W2167956058
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28558568
Keywords
Focal adhesion, Cell biology, Extracellular matrix, PTK2, Integrin
References
- Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets
- Integrins: versatility, modulation, and signaling in cell adhesion.
- An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3- mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation
- Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells
- Studies on proteins that co-purify with smooth muscle vinculin: identification of immunologically related species in focal adhesions of nonmuscle and Z-lines of muscle cells
- Complementary adhesive responses of human skin fibroblasts to the cell-binding domain of fibronectin and the heparan sulfate-binding protein, platelet factor-4.
- The Novel Structural Motif Gln795–Gln802 in the Integrin β1C Cytoplasmic Domain Regulates Cell Proliferation (*)
- Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.
- Small GTP-binding proteins and the regulation of the actin cytoskeleton.
- Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells
- Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.
- Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1
- Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase.
- The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
- rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.
- A novel type of myosin implicated in signalling by rho family GTPases.
- The mammalian G protein rhoC is ADP‐ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.
- Association of the amino‐terminal half of c‐Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.
- A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin‐based cytoskeleton of mammalian cells.
- ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.
Cited by
- Biomimetic replication of intestinal basement membrane topography
- Evaluation of matricellular proteins as potential therapeutics for the treatment of human chronic skin wounds
- Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly
- Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells.
- Restricted and coordinated expression of beta3-integrin and bone sialoprotein during cultured osteoblast differentiation.
- Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells
- Quantitative Relationship among Integrin-Ligand Binding, Adhesion, and Signaling via Focal Adhesion Kinase and Extracellular Signal-regulated Kinase 2*
- Tyrosine phosphorylation and subcellular localization of focal adhesion proteins during in vitro decidualization of human endometrial stromal cells.
- Integrin signaling's potential for mediating gene expression in hypertrophying skeletal muscle.
- Myosin light chain phosphorylation‐dependent modulation of volume‐regulated anion channels in macrovascular endothelium
- Role of Rho in Ca(2+)-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle.
- Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas).
- Myosin Light Chain Kinase Inhibitors Can Block Invasion and Adhesion of Human Pancreatic Cancer Cell Lines
- Myofibroblasts and mechano-regulation of connective tissue remodelling
- Characterization of PINCH-2, a New Focal Adhesion Protein That Regulates the PINCH-1-ILK Interaction, Cell Spreading, and Migration*
- Antiapoptotic Action of Focal Adhesion Kinase (FAK) Against Ionizing Radiation
- Tumour-cell invasion and migration: diversity and escape mechanisms
- Mass transfer in porous tissue engineering scaffolds
- Modulation of Thr Phosphorylation of Integrin β1 during Muscle Differentiation*
- Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
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