Role of genes and environments for explaining Alzheimer disease.
Explore this paper's citation graph
Summary
In the largest twin study to date, heritability for AD is high and that the same genetic factors are influential for both men and women, however, nongenetic risk factors also play an important role and might be the focus for interventions to reduce disease risk or delay disease onset.
- Type
- article
- Published
- 2006-02-01
- Cited by
- 1,754
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2166336042
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25671256
Keywords
Heritability, Twin study, Monozygotic twin, Disease, Dizygotic twins
References
- Documentation and Evaluation of Cognitive Impairment in Elderly Primary Care Patients
- Sources of covariation among Mini-Mental State Examination scores, education, and cognitive abilities.
- Prevalence of Alzheimer's disease and other dementias in an elderly urban population
- Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
- Characteristics of Two Telephone Screens for Cognitive Impairment
- The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
- Clinical, neuroimaging, and environmental risk differences in monozygotic female twins appearing discordant for dementia of the Alzheimer type.
- Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study
- Anatomic, metabolic, neuropsychological, and molecular genetic studies of three pairs of identical twins discordant for dementia of the Alzheimer's type.
- Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study.
- How heritable is Alzheimer's disease late in life? Findings from Swedish twins
- Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment.
- Genetic Factors in Alzheimer's Disease
- P4-137 Alzheimer's disease in the NAS-NRC twin registry of WWII veterans
- The blessed dementia scale as a screening test for dementia
- A 90-year-old monozygotic female twin pair discordant for Alzheimer's disease.
- Alzheimer's disease in Finnish twins.
- A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease.
- Adjustment of twin data for the effects of age and sex
- Heritability for Alzheimer's disease: the study of dementia in Swedish twins.
Cited by
- Identification of Functional Variants in Alzheimer's Disease-Associated Genes
- Genetik der kognitiven Fähigkeiten in der Lebensspanne
- Amyloid-β: the seeds of darkness.
- Exacerbated CSF abnormalities in younger patients with Alzheimer's disease.
- Evidence for modest familial co-aggregation between dementia and parkinsonism
- Clinical Genetics of Alzheimer's Disease
- RNA-Sequencing to Elucidate Early Patterns of Dysregulation Underlying the Onset of Alzheimer's Disease.
- The genetic landscape of Alzheimer disease: clinical implications and perspectives
- Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers
- State of Play in Alzheimer’s Disease Genetics
- Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly
- Synergistic interaction between APOE and family history of Alzheimer’s disease on cerebral amyloid deposition and glucose metabolism
- Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?
- Études d’association pangénomique appliquées à la recherche de nouveaux facteurs de risque génétique de la maladie d’Alzheimer
- Differential Localization of Hic-5 and Paxillin in the Brain of Alzheimer's Disease Subjects
- Rôle des ADAM dans le processus physiopathologique de la maladie d'Alzheimer
- Analysis of Reelin function in the molecular mechanisms underlying Alzheimer’s disease
- Analysis of the costs of medical interventions in Alzheimer's Disease as they affect Long-Term Care
- [Genetic aspects of Alzheimer's disease (Review)].
- Two polymorphisms of RCAN1 gene associated with Alzheimer's disease in the Chinese Han population.
Related papers
- X-inactivation patterns in monozygotic and dizygotic female twins.
- Genetic influences on ambulatory blood pressure patterns. The Medical College of Virginia Twin Study.
- Heritability of Personality
- The potential use of artificially produced monozygotic twins for comparative experiments.
- A study of developmental speech and language disorders in twins.
- Hypothalamus volume in twin pairs discordant for schizophrenia.
- Does Higher Concordance in Monozygotic Twins Than in Dizygotic Twins Suggest a Genetic Component?
- Familial determinants of moderate and intense physical activity: a twin study.
- A twin concordance study of trichotillomania