Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.
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Summary
A regulatory linkage between the function of two oncogenes--c-myc and c-sis--the latter being the putative structural gene for PDGF is suggested, consistent with a model that a labile protein may regulate c- myc levels in these cells.
- Type
- article
- Published
- 1983-12-01
- Cited by
- 1,947
- References
- 42
- OpenAlex
- https://openalex.org/W2164515753
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1452646
Keywords
Biology, Cycloheximide, Growth factor, Molecular biology, Concanavalin A
References
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- Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
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- RNA processing errors in patients with beta-thalassemia.
- Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor
- Growth in size and cell DNA replication.
- Evidence for an interleukin-independent pathway for human lymphocyte activation.
- Correlation between cell cycle duration and RNA content
- Continuous protein synthesis is required to maintain the probability of entry into S phase.
- Cellular transforming genes.
- Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells
- Translocations among antibody genes in human cancer.
Cited by
- Regulation of Myc: Max complex formation and its potential role in cell proliferation.
- Cyclosporin A and FK506 prevent the derepression of the IL-2 gene in mitogen-induced primary T lymphocytes.
- B cell activation and apoptosis.
- Nuclear colocalization of c-myc protein and hsp70 in cells transfected with human wild-type and mutant c-myc genes.
- Stimulation of 1,25‐dihydroxyvitamin D3 receptor gene expression in cultured cells by serum and growth factors
- Steroid modulation of the expression of growth factors and oncogenes in breast cancer.
- Elevated Expression of Proto‐Oncogenes during Interleukin‐5‐Induced Growth and Differentiation of Murine B Lineage Cells
- A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle.
- Expression of c‐myc, c‐raf‐1, and c‐Ki‐ras in azaserine‐induced pancreatic carcinomas and growing pancreas in rats
- Cell-type-specific early response gene expression during plasmacytoid differentiation of human B lymphocytic leukemia cells.
- Comparative analysis of the involvement of p53, c-myc and c-fos in epidermal growth factor-mediated signal transduction.
- The same external signal differentially induced the c-myc expression in Burkitt lymphoma and B-lymphoblastoid cell lines.
- Regulation of DNA synthesis investigated in heterokaryons of dividing and nondividing cells.
- The replication activity of SV40 DNA correlates with the level of c-myc expression in human tumor cell lines.
- The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response.
- Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor
- Myc family of cellular oncogenes
- Recessive genetic deregulation abrogates c-myc suppression by interferon and is implicated in oncogenesis
- Chemoattractant-induced activation of c-fos gene expression in human monocytes
- Probability that the commitment of murine erythroleukemia cell differentiation is determined by the c-myc level.
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