Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells
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Summary
Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes.
- Type
- article
- Published
- 1982-01-14
- Cited by
- 454
- References
- 42
- OpenAlex
- https://openalex.org/W2013911067
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4355419
Keywords
Retrovirus, Gene, Biology, Genome, Human genome
References
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- Direct transformation of 3T3 cells by Abelson murine leukaemia virus
- Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
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- Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus.
- DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
- Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.
- Avian leukemia viruses: interaction with their target cells in vivo and in vitro.
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- Transforming activity of human tumor DNAs.
Cited by
- Molecular oncogenetics of metastasis.
- Oncogenes
- The pathophysiology of murine retrovirus-induced leukemias.
- The metabolic defect of methionine dependence occurs frequently in human tumor cell lines.
- Mechanisms of neoplastic transformation.
- Chromosomal sublocalization of human c-myb and c-fes cellular onc genes
- A comparison of clonogenic, microtetrazolium and sulforhodamine B assays for determination of cisplatin cytotoxicity in human ovarian carcinoma cell lines.
- The oncogene and its potential role in carcinogenesis.
- Phosphotyrosyl-protein phosphatases.
- Current understanding of virus etiology in leukemia.
- The human onc gene c-myc: structure, expression, and amplification in the human promyelocytic leukemia cell line HL-60.
- Oncogene expression in human leukemia.
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- Viral oncogenes and cellular prototypes.
- Mechanisms for cisplatin-FUra synergism and cisplatin resistance in human ovarian carcinoma cells both in vitro and in vivo.
- Activation of the c-myc oncogene.
- Enhanced transcription of the cytosolic ALDH gene in cyclophosphamide resistant human carcinoma cells.
- Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.
- Cellular onc genes: their role as progenitors of viral onc genes and their expression in human cells.
- Mechanisms of resistance to cisplatin and alkylating agents.
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