K+ efflux is the Common Trigger of NLRP3 inflammasome Activation by Bacterial Toxins and Particulate Matter
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Summary
This work shows that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP and particulate matter caused mitochondrial perturbation or the opening of a large membrane pore; but this was not required for NLRP3 activation.
- Type
- article
- Published
- 2013-06-27
- Cited by
- 2,008
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2079882002
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205418591
Keywords
Inflammasome, Efflux, Biology, Microbial toxins, Particulates
References
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- Lysosomes in cell death
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome During Apoptosis
Cited by
- DISSECTING THE MECHANISM OF NLRP3 INFLAMMASOME ACTIVATION IN INDIVIDUAL CELLS: THE ROLE OF REACTIVE OXYGEN SPECIES AND ORGANELLE DAMAGE
- Ca2+ signaling but not store-operated Ca2+ entry (SOCE) is required for the function of macrophages and dendritic cells
- Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
- WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3
- A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells.
- Metabolic regulation of NLRP3
- The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation.
- Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages
- Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review).
- Pyroptosis versus necroptosis: similarities, differences, and crosstalk
- Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
- A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
- Metabolic signals and innate immune activation in obesity and exercise.
- NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS ARE ANTI-INFLAMMATORY AND TARGET DRY AGE-RELATED MACULAR DEGENERATION
- Inflammasome Priming Is Similar for Francisella Species That Differentially Induce Inflammasome Activation
- Elucidating the Role of HDAC8 in Anthrax Lethal Toxin-Induced Pyroptosis and Cytokine Gene Silencing in Macrophages
- Mycobacterium tuberculosis and the human macrophage : shifting the balance through inflammasome activation
- Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages
- Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation
- Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular
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