Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
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Summary
The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased TMAO levels are associated with an increased risk of incident major adverse cardiovascular events.
- Type
- article
- Published
- 2013-04-24
- Cited by
- 3,010
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2162078360
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:58605737
Keywords
Phosphatidylcholine, Choline, Metabolism, Metabolite, Medicine
References
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- Lipid metabolism by gut microbes and atherosclerosis.
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- Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
- Metagenomic Analysis of the Human Distal Gut Microbiome
- Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Cited by
- Archaea and the human gut: new beginning of an old story.
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research
- Nonextracorporeal methods for decreasing uremic solute concentration: a future way to go?
- The Gut Microbial Endocrine Organ: Bacterially-Derived Signals Driving Cardiometabolic Diseases
- A New Model of Reverse Cholesterol Transport: EnTICEing Strategies to Stimulate Intestinal Cholesterol Excretion
- Nutrition and the science of disease prevention: a systems approach to support metabolic health
- Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease.
- Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling.
- Microbiome-wide association studies link dynamic microbial consortia to disease
- Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease
- Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery
- Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration
- Novel Risk Stratification Assays for Acute Coronary Syndrome
- Postprandial gut microbiota-driven choline metabolism links dietary cues to adipose tissue dysfunction
- Uremic Toxin Clearance and Cardiovascular Toxicities
- Mediterranean Diet Score: Associations with Metabolic Products of the Intestinal Microbiome, Carotid Plaque Burden, and Renal Function
- Microbiome: Focus on causation and mechanism
- Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention
- The gene expression and bioinformatic analysis of choline trimethylamine-lyase (CutC) and its activating enzyme (CutD) for gut microbes and comparison with their TMA production levels
- Gut Microbiota and Complications of Type-2 Diabetes
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