Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery
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Summary
The gut microbe-derived metabolite trimethylamine N-oxide has been causally linked to the development of cardiovascular diseases and drugging this pathway can inhibit atherosclerosis development in mice.
- Type
- article
- Published
- 2017-04-07
- Cited by
- 97
- References
- 103
- Access
- Open access
- OpenAlex
- https://openalex.org/W28389555
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28485765
Keywords
Computer science
References
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- Living with water stress: evolution of osmolyte systems.
- Microbiota‐dependent metabolite trimethylamine‐N‐oxide is associated with disease severity and survival of patients with chronic heart failure
- Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
- Synchronous evolution of an odor biosynthesis pathway and behavioral response
- Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine
- Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine
Cited by
- Postprandial gut microbiota-driven choline metabolism links dietary cues to adipose tissue dysfunction
- Introduction to the Thematic Minireview Series: Host-microbiome metabolic interplay
- Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity.
- Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.
- Trimethylamine N-oxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet
- Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiota.
- Microbiome series
- Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites
- Trimethylamine N-oxide and ACE inhibitors: fighting a new enemy with an established weapon?
- Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker
- Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
- Accessing Bioactive Natural Products from the Human Microbiome
- Trace Amines and Their Receptors
- Development of a gut microbe-targeted non-lethal therapeutic to inhibit thrombosis potential
- Contribution of the commensal microbiota to atherosclerosis and arterial thrombosis
- Role of Microbiome in Carcinogenesis Process and Epigenetic Regulation of Colorectal Cancer.
- Dietary metabolism, the gut microbiome, and heart failure
- Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
- Using Enteric Pathogens to Probe the Gut Microbiota.
- Pancreatic and mucosal enzymes in choline phospholipid digestion.
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