Relationship between microtubule‐binding repeats and morphology of neurofibrillary tangle in Alzheimer's disease
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Summary
Comparison of the distributions of three‐repeat (3R) and four‐ repeat (4R) neurofibrillary tangles (NFT) with those of pretangles (p‐NFT), intracellular NFT, i-NFT, and extracellular N FT (e‐N FT) in the hippocampus of Alzheimer's disease brains is performed.
- Type
- article
- Published
- 2005-11-01
- Cited by
- 17
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2155810540
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23667558
Keywords
Tangle, Neurofibrillary tangle, Morphology (biology), Alzheimer's disease, Microtubule
References
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- Anti-tau phospho-specific Ser262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains
- Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence
- Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy
- Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration
- The microtubule binding domain of tau protein.
- A protein factor essential for microtubule assembly.
- Regional quantitative analysis of NFT in brains of non‐demented elderly persons: Comparisons with findings in brains of late‐onset Alzheimer’s disease and limbic NFT dementia
- Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
- Regional Analysis of Differently Phosphorylated Tau Proteins in Brains from Patients with Alzheimer’s Disease
- Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles.
- Sporadic Pick's disease: A tauopathy characterized by a spectrum of pathological τ isoforms in gray and white matter
- A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
- Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities
- Senile Dementia of the Neurofibrillary Tangle Type: A Comparison with Alzheimer’s Disease
- Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific monoclonal antibodies
- Regional quantitative study of formation process of neurofibrillary tangles in the hippocampus of non‐demented elderly brains: Comparison with late‐onset Alzheimer's disease brains
- Neuropathological stageing of Alzheimer-related changes
- Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
- The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Cited by
- Pretangles and neurofibrillary changes: Similarities and differences between AD and CBD based on molecular and morphological evolution
- The Link Between DYRK1A Overexpression and Several-fold Enhancement of Neurofibrillary Degeneration with 3-Repeat Tau Protein in Down Syndrome
- Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology
- Tangle evolution linked to differential 3- and 4-repeat tau isoform deposition: a double immunofluorolabeling study using two monoclonal antibodies
- Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia.
- 14‐3‐3 protein beta isoform is associated with 3‐repeat tau neurofibrillary tangles in Alzheimer's disease
- Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease
- Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies.
- Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β
- Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
- Oligomeric, phosphorylated, truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer’s disease
- Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome
- The Current Role of Tau PET Imaging in Neurodegeneration.
- A View on Early Diagnosis of Dementias from Neuropathology
- Imaging of Neurotransmitter Systems in Dementia
- Title : Brainstem tau pathology in Alzheimer ’ s disease is characterized by increase of three repeat tau and independent of amyloid β Author Names
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