Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
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Summary
A neural network-based tool, TargetP, for large-scale subcellular location prediction of newly identified proteins has been developed and it is estimated that 10% of all plant proteins are mitochondrial and 14% chloroplastic, and that the abundance of secretory proteins, in both Arabidopsis and Homo, is around 10%.
- Type
- article
- Published
- 2000-07-21
- Cited by
- 4,386
- References
- 55
- OpenAlex
- https://openalex.org/W2152458080
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30441491
Keywords
Chloroplast, Signal peptide, Arabidopsis, Biology, Arabidopsis thaliana
References
- Transport of proteins to the mitochondrial intermembrane space: the ‘matrix‐targeting’ and the ‘sorting’ domains in the cytochrome c1 presequence.
- Signal sequences. The limits of variation.
- Recognition and Binding of Mitochondrial Presequences during the Import of Proteins into Mitochondria
- Transport of proteins into chloroplasts. Partial purification of a chloroplast protease involved in the processing of important precursor polypeptides.
- Mitochondrial intermediate peptidase.
- Rapid and sensitive sequence comparison with FASTP and FASTA.
- Fitting a Mixture Model By Expectation Maximization To Discover Motifs In Biopolymer
- Processing of mitochondrial precursor proteins.
- Local alignment statistics.
- Neural Network Prediction of Translation Initiation Sites in Eukaryotes: Perspectives for EST and Genome Analysis
- Conversion of a Nonprocessed Mitochondrial Precursor Protein into One That Is Processed by the Mitochondrial Processing Peptidase (*)
- A conserved cleavage‐site motif in chloroplast transit peptides
- Transport of proteins across the endoplasmic reticulum membrane.
- A knowledge base for predicting protein localization sites in eukaryotic cells
- Mitochondrial targeting sequences why ‘non‐amphiphilic’ peptides may still be amphiphilic
- Issues in searching molecular sequence databases
- The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
- Prediction of human mRNA donor and acceptor sites from the DNA sequence.
- Using neural networks for prediction of the subcellular location of proteins.
- Common Principles of Protein Translocation Across Membranes
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- Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).
- Two isoforms of Saccharomyces cerevisiae glutaredoxin 2 are expressed in vivo and localize to different subcellular compartments.
- A nucleus-encoded maize protein with sigma factor activity accumulates in mitochondria and chloroplasts.
- In silico prediction of the peroxisomal proteome in fungi, plants and animals.
- A Transcriptomic and Proteomic Characterization of the Arabidopsis Mitochondrial Protein Import Apparatus and Its Response to Mitochondrial Dysfunction1[w]
- NADP-malic enzyme and Hsp70: co-purification of both proteins and modification of NADP-malic enzyme properties by association with Hsp70.
- The role of alternative translation start sites in the generation of human protein diversity
- New, emerging roles for cardiac connexins. Mitochondrial Cx43 raises new questions.
- Suppression of Allene Oxide Cyclase in Hairy Roots of Medicago truncatula Reduces Jasmonate Levels and the Degree of Mycorrhization with Glomus intraradices1[w]
- The role of the N‐terminal domain of chloroplast targeting peptides in organellar protein import and miss‐sorting
- ATTED-II: a database of co-expressed genes and cis elements for identifying co-regulated gene groups in Arabidopsis
- Characterization and localization of Plasmodium falciparum homolog of prokaryotic ClpQ/HslV protease.
- The Senescence-Induced Staygreen Protein Regulates Chlorophyll Degradation[W]
- Molecular cloning and characterization of a mannose-binding lectin gene from Pinellia cordata
- A Model for Carbohydrate Metabolism in the Diatom Phaeodactylum tricornutum Deduced from Comparative Whole Genome Analysis
- Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis[W][OA]
- Targeting of nucleus-encoded proteins to chloroplasts in plants.
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