Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications.
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Summary
This review focuses on the main age-related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.
- Type
- review
- Published
- 2003-11-14
- Cited by
- 1,783
- References
- 128
- Access
- Open access
- OpenAlex
- https://openalex.org/W2149485684
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39267899
Keywords
Pharmacodynamics, Pharmacokinetics, Homeostasis, Pharmacology, Medicine
References
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- Relationship between diazepam dose, plasma level, age, and central nervous system depression
- Renal handling of drugs in the healthy elderly Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged
- Digoxin in the elderly: Pharmacokinetic consequences of old age
- Aging and ethanol metabolism
- Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine.
- Clinical cardiac electrophysiology ; techniques and interpretations
- Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging
- The efficacy, safety, and tolerability of antipsychotics in the elderly.
- Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium).
- Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man.
- Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine.
- Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs
- STUDIES IN OLD AGE: IV. THE CLINICAL SIGNIFICANCE OF SALIVARY, GASTRIC AND PANCREATIC SECRETION IN THE AGED
- Effects of Age and Aerobic Capacit on Arterial Stiffness in Healthy Adults
- Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension.
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- Diagnosis and treatment of glomerular diseases in elderly patients.
- Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud
- Pharmacotherapy Considerations in Elderly Adults
- Geriatric pharmacotherapy: Appraising new drugs for neurologic disorders in older patients.
- Team Approach: Preoperative Management of Metabolic Conditions in Total Joint Replacement.
- Clinically Relevant Drug-Drug and Drug-Food Interactions
- Management of chronic heart failure in the older population
- Pharmacokinetics of twice-daily versus once-daily dosing with granular slow-release para-aminosalicylic acid in adults on second-line anti-tuberculosis and antiretroviral treatment
- Psykofarmaka : En riskfaktor för fall hos äldre?
- Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: secondary analysis of a cross-sectional study
- Use of Sorafenib in Two Metastatic Renal Cell Cancer Patients with End-Stage Renal Impairment Undergoing Replacement Hemodialysis
- Prescribing for older people with chronic renal impairment.
- Implicações do envelhecimento na terapêutica farmacológica
- Adesão ao regime medicamentoso em idosos na comunidade : eficácia das intervenções de enfermagem
- Physiology of aging of older adults: systemic and oral health considerations.
- Medicines in the context of older people's lives
- Clinical pharmacy services within a multiprofessional healthcare team
- Identifying knowledge gaps in the labeling of medications for geriatric patients.
- Pharmacogenetic Epidemiology of Statins in an Ageing Population
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