Signals for sorting of transmembrane proteins to endosomes and lysosomes.
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Summary
This work has shown that peptide motifs serve as a signal for sorting at various stages of the endosomal-lysosomal system and several proteins, including clathrin, AP-2, and Dab2, have been proposed to function as recognition proteins for NPXY signals.
- Type
- review
- Published
- 2003-11-28
- Cited by
- 2,183
- References
- 312
- OpenAlex
- https://openalex.org/W2148351021
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17233492
Keywords
Endosome, Protein Sorting Signals, Protein targeting, Transmembrane protein, Cell biology
References
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- A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.
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- Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor
- The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides.
- In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting.
- The ubiquitin conjugation system is required for ligand‐induced endocytosis and degradation of the growth hormone receptor.
- Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.
- Transplanted LDL and mannose‐6‐phosphate receptor internalization signals promote high‐efficiency endocytosis of the transferrin receptor.
- Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor.
- Ubiquitin and proteasomes: Protein regulation by monoubiquitin
- Acidification-dependent dissociation of endocytosed insulin precedes that of endocytosed proteins bearing the mannose 6-phosphate recognition marker.
- Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.
- Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking
- Proteins containing the UBA domain are able to bind to multi-ubiquitin chains
- Accessory factors in clathrin-dependent synaptic vesicle endocytosis
- A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.
- Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography.
- Phosphorylation of the cytoplasmic domain of the bovine cation-independent mannose 6-phosphate receptor. Serines 2421 and 2492 are the targets of a casein kinase II associated to the Golgi-derived HAI adaptor complex.
Cited by
- Clathrin/AP-2-dependent endocytosis: a novel playground for the pharmacological toolbox?
- Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation
- Mechanism of ubiquitin recognition by the CUE domain of Vps9p.
- Ligand Binding Determines Whether CD46 Is Internalized by Clathrin-coated Pits or Macropinocytosis*
- Reconstructing the evolution of the endocytic system: insights from genomics and molecular cell biology.
- The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei
- LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans
- Extracellular release of BACE1 holoproteins from human neuronal cells.
- Protein posttranslational modifications: the chemistry of proteome diversifications.
- Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling.
- A pre-synaptic to-do list for coupling exocytosis to endocytosis.
- TNF Trafficking to Human Mast Cell Granules: Mature Chain-Dependent Endocytosis1
- Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.
- Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis.
- Uncommon Endocytic and Trafficking Pathway of the Natural Killer Cell CD94/NKG2A Inhibitory Receptor
- Localization of human (pro)renin receptor lacking the transmembrane domain on budded baculovirus of Autographa californica multiple nucleopolyhedrovirus
- A Distributed Set of Interactions Controls μ2 Functionality in the Role of AP-2 as a Sorting Adaptor in Synaptic Vesicle Endocytosis*♦
- Polarized targeting of DNER into dendritic plasma membrane in hippocampal neurons depends on endocytosis
- Shaping membranes for endocytosis.
- Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes.
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